Special Issue "Multi-Drug Resistant Bacteria—A Global Problem"
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 4627
Interests: drug-resistance mechanisms; beta-lactamases; multi-drug resistance (MDR); efflux pumps; MDR clinical and environmental bacterial strains; non-fermentative Gram-negative rods; new antibacterial compounds; bacterial adaptation to disinfectants
2. Department of Antibiotics and Microbiology, National Drug Institute, Chelmska 30/34 Str., 00-725 Warsaw, Poland
Interests: drug-resistance mechanisms; antibiotics’ mechanisms of activity; antimicrobial chemotherapeutics; antimicrobial agents; antisepsis and disinfection; quality of antimicrobial medicines
The growing number of isolated multi-drug resistant clinical and environmental bacterial strains and the ability to produce and transmit resistance mechanisms to antibiotics and antibacterial chemotherapeutics have become an increasing problem in combating worldwide infections in recent years. As the WHO points out, one of the main elements in fighting the problem of microbial resistance is an in-depth understanding of the underlying resistance mechanisms. In this Special Issue, we plan to collect original research articles and review articles concerning the molecular basis of resistance mechanisms against antimicrobial agents (e.g., antibiotics, new antibacterial substances and disinfectants) in Gram-positive and Gram-negative bacteria. These strains may be present in the natural environment (water, soil and air) and healthcare environment and, mostly, can be isolated from clinical and veterinary materials. The multi-drug resistance observed in bacterial strains is due to the acquisition and interaction of several various resistance mechanisms. Today, the most dangerous are resistance genes localized in mobile genetic elements.
Prof. Dr. Agnieszka Laudy
Prof. Dr. Stefan Tyski
Manuscript Submission Information
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- MDR bacterial strains
- Drug-resistance mechanisms
- Antibiotic-resistance genes
- Acquired resistance
- Mobile genetic elements
- Transmission of resistance genes
- Regulation of resistance-gene expression
- Enzymatic mechanisms of drug resistance
- Efflux pumps
- Drug influx
- Cell wall and outer membrane porins
- Cell membrane permeability
- Modification of enzymatic pathways
- Antibacterial-agent targets
- New antibacterial agents
- Resistance to antibiotics
- Resistance to antimicrobial agents
- Resistance to antiseptics and disinfectants
- Bacterial pathogenic strains
- Resistant environmental strains
- Resistant clinical strains