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Mitochondrial Dysfunction in Ageing and Diseases
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Mitochondrial Dysfunction in Ageing and Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (25 May 2015) | Viewed by 248830

Printed Edition Available!
A printed edition of this Special Issue is available here.

Special Issue Editors

Prof. Dr. Lars Olson

E-Mail Website
Guest Editor
Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden
Interests: monoamine neurons, development, growth factors, regeneration, aging, transplantation in the central nervous system, models for Parkinson’s disease and its treatment, models for spinal cord injury and treatment strategies, the roles of transcription factors in the nervous system, genetic risk factors for Parkinson’s disease, brain plasticity, memory and the Nogo signaling system
Dr. Jaime M. Ross

E-Mail Website
Guest Editor
Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden
Interests: mitochondrial dysfunction, metabolism, development, models for ageing and neurodegenerative diseases and possible treatments
Dr. Giuseppe Coppotelli

E-Mail Website
Guest Editor
Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden
Interests: protein homeostasis, mitochondrial dysfunction, models for ageing and age-related diseases and treatment strategies

Special Issue Information

Dear Colleagues,

The past decade has witnessed an explosion of knowledge regarding how mitochondrial dysfunction may translate into ageing and disease phenotypes, as well as how it is modulated by genetic and lifestyle factors. Impairment of the mitochondria may be caused by mutations or deletions in nuclear or mitochondrial DNA. Hallmarks of mitochondrial dysfunction include decreased ATP production, decreased mitochondrial membrane potential, swollen mitochondria, damaged cristae, increased oxidative stress, and decreased mitochondrial DNA copy number. In addition to energy production, mitochondria play an important role in regulating apoptosis, buffering calcium release, retrograde signaling to the nuclear genome, producing reactive oxygen species (ROS), participating in steroid synthesis, signaling to the immune system, as well as controlling the cell cycle and cell growth. Dysfunctional mitochondria have been implicated in ageing and in several diseases, many of which are age-related, including mitochondrial diseases, cancers, metabolic diseases and diabetes, inflammatory conditions, neuropathy, and neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Additionally, a possible link between mitochondrial metabolism and the ubiquitin-proteasome and autophagy-lysosome systems is emerging as a novel factor contributing to the progression of several human diseases.

This special issue calls for original research, mini and full reviews, and perspectives that address the progress and current standing in the vast field of mitochondrial biology. These include, but are not limited to:

  • ageing
  • neurodegenerative diseases
  • mitochondrial diseases
  • metabolic diseases
  • protein homeostasis
  • cell/retrograde signaling
  • oxidative stress
  • pain
  • cancer
  • immune system
  • therapies to counteract mitochondrial dysfunction

Dr. Giuseppe Coppotelli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


Keywords

  • ageing
  • neurodegenerative diseases
  • mitochondrial diseases
  • metabolic diseases
  • protein homeostasis
  • cell/retrograde signalling
  • oxidative stress
  • pain
  • cancer
  • immune system
  • therapies to counteract mitochondrial dysfunction

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Published Papers (22 papers)

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5 pages, 161 KiB  
Editorial
Mitochondria in Ageing and Diseases: The Super Trouper of the Cell
Int. J. Mol. Sci. 2016, 17(5), 711; https://doi.org/10.3390/ijms17050711 - 11 May 2016
14 pages, 1062 KiB  
Review
Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors
Int. J. Mol. Sci. 2015, 16(11), 27313-27326; https://doi.org/10.3390/ijms161126020 - 13 Nov 2015
19 pages, 1847 KiB  
Article
Low T3 State Is Correlated with Cardiac Mitochondrial Impairments after Ischemia Reperfusion Injury: Evidence from a Proteomic Approach
Int. J. Mol. Sci. 2015, 16(11), 26687-26705; https://doi.org/10.3390/ijms161125973 - 6 Nov 2015
18 pages, 2920 KiB  
Article
Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury
Int. J. Mol. Sci. 2015, 16(9), 22509-22526; https://doi.org/10.3390/ijms160922509 - 17 Sep 2015
34 pages, 1027 KiB  
Review
The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis
Int. J. Mol. Sci. 2015, 16(9), 21486-21519; https://doi.org/10.3390/ijms160921486 - 7 Sep 2015
27 pages, 727 KiB  
Review
Mitochondria: A Therapeutic Target for Parkinson’s Disease?
Int. J. Mol. Sci. 2015, 16(9), 20704-20730; https://doi.org/10.3390/ijms160920704 - 1 Sep 2015
15 pages, 1319 KiB  
Review
Mitochondrial Transcription Factor A and Mitochondrial Genome as Molecular Targets for Cisplatin-Based Cancer Chemotherapy
Int. J. Mol. Sci. 2015, 16(8), 19836-19850; https://doi.org/10.3390/ijms160819836 - 20 Aug 2015
19 pages, 1973 KiB  
Review
Mitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin?
Int. J. Mol. Sci. 2015, 16(8), 19458-19476; https://doi.org/10.3390/ijms160819458 - 17 Aug 2015
28 pages, 2630 KiB  
Review
Mitochondria Retrograde Signaling and the UPRmt: Where Are We in Mammals?
Int. J. Mol. Sci. 2015, 16(8), 18224-18251; https://doi.org/10.3390/ijms160818224 - 6 Aug 2015
23 pages, 1359 KiB  
Review
Genes and Pathways Involved in Adult Onset Disorders Featuring Muscle Mitochondrial DNA Instability
Int. J. Mol. Sci. 2015, 16(8), 18054-18076; https://doi.org/10.3390/ijms160818054 - 5 Aug 2015
16 pages, 880 KiB  
Review
Mitochondrial Mechanisms in Septic Cardiomyopathy
Int. J. Mol. Sci. 2015, 16(8), 17763-17778; https://doi.org/10.3390/ijms160817763 - 3 Aug 2015
28 pages, 785 KiB  
Review
Treatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer Agents
Int. J. Mol. Sci. 2015, 16(8), 17394-17421; https://doi.org/10.3390/ijms160817394 - 29 Jul 2015
18 pages, 934 KiB  
Review
Thyroid Hormone Mediated Modulation of Energy Expenditure
Int. J. Mol. Sci. 2015, 16(7), 16158-16175; https://doi.org/10.3390/ijms160716158 - 16 Jul 2015
18 pages, 1487 KiB  
Review
Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link
Int. J. Mol. Sci. 2015, 16(7), 16067-16084; https://doi.org/10.3390/ijms160716067 - 15 Jul 2015
36 pages, 2109 KiB  
Review
Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction
Int. J. Mol. Sci. 2015, 16(7), 15918-15953; https://doi.org/10.3390/ijms160715918 - 13 Jul 2015
14 pages, 964 KiB  
Article
Mitochondria-Derived Reactive Oxygen Species Play an Important Role in Doxorubicin-Induced Platelet Apoptosis
Int. J. Mol. Sci. 2015, 16(5), 11087-11100; https://doi.org/10.3390/ijms160511087 - 15 May 2015
18 pages, 1023 KiB  
Review
Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA
Int. J. Mol. Sci. 2015, 16(5), 10870-10887; https://doi.org/10.3390/ijms160510870 - 13 May 2015
12 pages, 1125 KiB  
Review
Skeletal Muscle Mitochondrial Energetic Efficiency and Aging
Int. J. Mol. Sci. 2015, 16(5), 10674-10685; https://doi.org/10.3390/ijms160510674 - 11 May 2015
19 pages, 1892 KiB  
Article
Abnormal Mitochondrial Function and Impaired Granulosa Cell Differentiation in Androgen Receptor Knockout Mice
Int. J. Mol. Sci. 2015, 16(5), 9831-9849; https://doi.org/10.3390/ijms16059831 - 30 Apr 2015
25 pages, 843 KiB  
Review
Mitochondria as Key Targets of Cardioprotection in Cardiac Ischemic Disease: Role of Thyroid Hormone Triiodothyronine
Int. J. Mol. Sci. 2015, 16(3), 6312-6336; https://doi.org/10.3390/ijms16036312 - 19 Mar 2015
12 pages, 793 KiB  
Review
Autophagy as a Regulatory Component of Erythropoiesis
Int. J. Mol. Sci. 2015, 16(2), 4083-4094; https://doi.org/10.3390/ijms16024083 - 13 Feb 2015
40 pages, 820 KiB  
Review
Current Experience in Testing Mitochondrial Nutrients in Disorders Featuring Oxidative Stress and Mitochondrial Dysfunction: Rational Design of Chemoprevention Trials
Int. J. Mol. Sci. 2014, 15(11), 20169-20208; https://doi.org/10.3390/ijms151120169 - 5 Nov 2014
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