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Int. J. Mol. Sci. 2015, 16(2), 4083-4094;

Autophagy as a Regulatory Component of Erythropoiesis

State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha 410078, China
Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10065, USA
Laboratory of Membrane Biology, New York Blood Center, New York, NY 10065, USA
College of Life Science, Zhengzhou University, Zhengzhou 450001, China
Author to whom correspondence should be addressed.
Academic Editors: Jaime M. Ross and Giuseppe Coppotelli
Received: 8 January 2015 / Revised: 5 February 2015 / Accepted: 9 February 2015 / Published: 13 February 2015
(This article belongs to the Special Issue Mitochondrial Dysfunction in Ageing and Diseases)
Full-Text   |   PDF [793 KB, uploaded 13 February 2015]   |  


Autophagy is a process that leads to the degradation of unnecessary or dysfunctional cellular components and long-lived protein aggregates. Erythropoiesis is a branch of hematopoietic differentiation by which mature red blood cells (RBCs) are generated from multi-potential hematopoietic stem cells (HSCs). Autophagy plays a critical role in the elimination of mitochondria, ribosomes and other organelles during erythroid terminal differentiation. Here, the modulators of autophagy that regulate erythroid differentiation were summarized, including autophagy-related (Atg) genes, the B-cell lymphoma 2 (Bcl-2) family member Bcl-2/adenovirus E1B 19 kDa interacting protein 3-like (Nix/Binp3L), transcription factors globin transcription factor 1 (GATA1) and forkhead box O3 (FoxO3), intermediary factor KRAB-associated protein1 (KAP1), and other modulators, such as focal adhesion kinase family-interacting protein of 200-kDa (FIP200), Ca2+ and 15-lipoxygenase. Understanding the modulators of autophagy in erythropoiesis will benefit the autophagy research field and facilitate the prevention and treatment of autophagy-related red blood cell disorders. View Full-Text
Keywords: autophagy; modulators; erythropoiesis autophagy; modulators; erythropoiesis

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Zhang, J.; Wu, K.; Xiao, X.; Liao, J.; Hu, Q.; Chen, H.; Liu, J.; An, X. Autophagy as a Regulatory Component of Erythropoiesis. Int. J. Mol. Sci. 2015, 16, 4083-4094.

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