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Skeletal Muscle Mitochondrial Energetic Efficiency and Aging

Department of Biology, University of Naples "Federico II", Napoli I-80126, Italy
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Academic Editor: Lars Olson
Int. J. Mol. Sci. 2015, 16(5), 10674-10685; https://doi.org/10.3390/ijms160510674
Received: 9 February 2015 / Revised: 5 May 2015 / Accepted: 5 May 2015 / Published: 11 May 2015
(This article belongs to the Special Issue Mitochondrial Dysfunction in Ageing and Diseases)
Aging is associated with a progressive loss of maximal cell functionality, and mitochondria are considered a key factor in aging process, since they determine the ATP availability in the cells. Mitochondrial performance during aging in skeletal muscle is reported to be either decreased or unchanged. This heterogeneity of results could partly be due to the method used to assess mitochondrial performance. In addition, in skeletal muscle the mitochondrial population is heterogeneous, composed of subsarcolemmal and intermyofibrillar mitochondria. Therefore, the purpose of the present review is to summarize the results obtained on the functionality of the above mitochondrial populations during aging, taking into account that the mitochondrial performance depends on organelle number, organelle activity, and energetic efficiency of the mitochondrial machinery in synthesizing ATP from the oxidation of fuels. View Full-Text
Keywords: mitochondria; aging; skeletal muscle; proton leak mitochondria; aging; skeletal muscle; proton leak
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Crescenzo, R.; Bianco, F.; Mazzoli, A.; Giacco, A.; Liverini, G.; Iossa, S. Skeletal Muscle Mitochondrial Energetic Efficiency and Aging. Int. J. Mol. Sci. 2015, 16, 10674-10685.

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