Recent Advances in Tumor Microenvironment and Molecular Targeting in Multiple Myeloma and Chronic Lymphocytic Leukemia

Dear Colleagues,

Multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) are becoming the most prevalent hematological malignancies due to the incredible results achieved by the introduction of target therapy and immunotherapy. Unfortunately, these diseases unavoidably relapse and become incurable in the majority of patients. From a biological point of view, genomic alterations are already present in cancer cells from MM and CLL at their asymptomatic phase (i.e. when patients do not need treatment), supporting the idea that extrinsic mechanisms are needed to foster cancer progression. Indeed, both diseases are considered microenvironment-dependent malignancies, where cancer cells (aberrant plasma cells or mature B cells) co-operate with a supportive tissue microenvironment to generate chronic inflammation and severe immune effectors impairment.

To this end, this Special Issue “Recent Advances in Tumor Microenvironment and Molecular Targeting in Multiple Myeloma and Chronic Lymphocytic Leukemia” of the International Journal of Molecular Sciences focus on the biological, translational and clinical advances achieved by the targeting of tumor microenvironment and of actionable genomic lesions as well as on the mechanisms at the basis of treatment resistance, thus paving the way for the design of better treatment strategies.

We welcome original basic, translational and molecular biology-driven clinical research articles as well as review articles leading to improvement of the understanding of both MM and CLL pathogenesis.

Dr. Cirino Botta
Dr. Massimo Gentile
Guest Editors

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