Molecular Advances in Cancer and Cell Metabolism—2nd Edition

Dear Colleagues,

Over the years, studies of cellular functions have allowed us to highlight how metabolism can be reprogrammed to support its links to many biological processes ranging from macromolecular synthesis to ATP production; in addition, cells continuously respond to different stimuli, growth factors, hormones, and changes in nutrient uptake by adapting metabolism to new conditions. Accumulating evidence suggests that metabolism can also regulate gene expression and signaling pathways, and its changes have significant impacts on many human diseases as well as recognized conditions associated with cancer.

The cellular metabolic phenotype is determined by the availability of metabolic substrates, oxygen levels, and interactions with the microenvironment where cells can proliferate and differentiate. The reprogramming of energy metabolism is a recognized hallmark of cancer cells that allows adaptation to new conditions of cell growth/survival through the metabolic switch from oxidative phosphorylation to glycolysis, when the aberrant proliferative capacity of cancer cells increases the energetic demands, contributing to the neoplastic transformation.

The aim of this Special Issue is to collect the current advances of the metabolic regulation in human normal and tumor cells to better characterize the biochemical mechanism differences associated with tumor metabolic reprogramming. Original articles, short communications, and reviews on physiological and pathological molecular pathways, including those that focus integrative omics techniques, are welcome.

We look forward to receiving your contributions.

Dr. Maria Concetta Faniello
Dr. Maria Mesuraca
Dr. Barbara Quaresima
Guest Editors

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