Special Issue "Immunoregulatory Receptor Signaling Networks"
Deadline for manuscript submissions: 31 May 2020.
Interests: comparative immunology; immunoregulatory receptor-types; innate immunity; inflammation; intracellular signaling; macrophages; phagocytosis; teleost
Innate immune cells (e.g., neutrophils, monocytes/macrophages, and natural killer cells) elicit potent effector responses capable of destroying a diverse range of invading pathogens. In general, these responses are controlled by immunoregulatory receptor-types that translate extracellular stimuli to complex, yet highly conserved, intracellular signaling networks. Depending on the immune cell-type and specific receptor activated, immunoregulatory signaling cascades trigger degranulation, phagocytosis, cell-mediated cytotoxicity, as well as the production of bioactive molecules. Prototypical immunoregulatory receptors are located in the plasma membrane, and structurally, they contain extracellular domains providing the interface for target recognition as well as transmembrane and cytoplasmic tail regions that can facilitate transmission of target binding into innate effector responses. Characteristically, these occur through a series of tyrosine-based and/or other intracellular biochemical signaling events. Generally, the broad classifications of immunoregulatory receptors as inhibitory or stimulatory have depended primarily on whether or not they contain key signaling motifs within their cytoplasmic regions (e.g., ITIMs and ITAMs). However, the functional outcome of immunoregulatory receptor engagement does not always precisely coincide with these canonical motifs, as alternative mechanisms of motif-dependent signaling events provide functional versatility among previously defined signaling networks. The magnitude and duration of receptor activation by natural ligands may also play a key role in the type of functional outcomes that occur following immunoregulatory receptor activation. In addition, the inherent modularity of signaling motifs within the transduction machinery allows for complex and novel regulatory behaviors to arise from relatively simple genetic events, such as recombination, deletion, or insertion. The heterogeneity observed within the intermolecular interactions between immunoregulatory receptor families (e.g., receptor crosstalk) also facilitates intricate tuning of responses through selective signaling dynamics. Finally, the presence of diverse immunoregulatory receptor families throughout immune cell lineages further compounds the apparent complexity required for the integrated control of innate immunity. In this Special Issue, we welcome reviews or data papers focused on understanding the dynamics of immunoregulatory receptor signaling networks using various vertebrate model systems. We also encourage the submission of papers describing new signaling pathways that further explore the versatility of immunoregulatory receptor signaling networks during inflammation.
Dr. James L. Stafford
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- innate immunity
- tyrosine-based signaling motifs
- intracellular signaling cascades
- immunoregulatory receptors
- cytoplasmic tail regions
- immunoregulatory receptor crosstalk
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Investigating Genetic and Epigenetic Pathogenesis of Hepatitis B virus for Drug Target Identification by Two-sided Time-profile Microarray Data via System Biology and Deep Learning Method
Authors: Bor-Sen Chen, etc.
Title: Protective effects of recombinant human soluble thrombomodulin on lipopolysaccharide-induced acute kidney injury
Authors: Yuji Nozaki, etc.
Title: Synergistic Activation of Toll-Like Receptors by Complementary Antigens as a Facilitator of Autoimmune Disease and Mediator of Sex Hormone-Associated Susceptibility: Review, Theory and Novel Predictions
Author: Robert Root-Bernstein
Title: Immunoregulatory Receptor Signaling Networks in regulating immune reactivity in drug hypersensitivity
Authors: Chun-Bing Chen, etc.
Title: Toll-like receptor 2 expression on myeloid dendritic cells correlates with endometriosis stage and clinical manifestations
Authors: Małgorzata Sobstyl, Ewelina Grywalska, Izabela Korona-Głowniak, Paulina Niedźwiedzka-Rystwej, Anna Sobstyl and Jan Kotarski
Title: The role of TLR on the immune response: PAMPs in OMV vaccines
Authors: Francesca Micoli, etc.
Title: Immunoregulatory Property of Inflammation-Assocociated Lung Diseases
Authors: Tatsuya Nagano, etc.
Title: A fish leukocyte immune-type receptor uses a novel intracytoplasmic tail networking mechanism to cross-inhibit ITAM-dependent phagocytic responses
Authors: Chenjie Fei, Myron A. Zwozdesky, and James L. Stafford
Title: The role of charge in binding of Nε-carboxymethyl lysine modified β-lactoglobulin to receptors for advanced glycation end products
Authors: Gosia Teodorowicz, etc.
Title: The Signalling Network of Macrophage Receptors, VEGFR-MERTK-PD-L1, in the Immunomodulation
Authors: Ko-Tung Chang, etc.