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Special Issue "Inflammatory/Immune Modulations by Old and New Glucocorticoids: From Cell to Medical Application"
Deadline for manuscript submissions: closed (23 October 2018).
Assoc. Prof. Dr. Giuseppe Nocentini Website E-Mail
Department of Medicine, University of Perugia, 06129 Perugia, Italy
Phone: +39 0755858186
Interests: Immunopharmacology; T lymphocyte co-stimulation; Regulatory T cell (Treg) modulation; Glucocorticoids; Immune checkpoint inhibitors; Cell therapy; Autoimmune diseases; Immuno-oncology
Despite their venerable age, glucocorticoids still challenge and surprise us. Their widespread use in clinical practice and their surprisingly tissue-specific actions in maintaining body homeostasis demand further studies to fully decipher their mechanisms of action. If we only consider the genomic and non-genomic effects of glucocorticoids, the long- and short-term effects of synthetic glucocorticoids, the opposite effects exerted on multiple types of immune cells, and their crucial roles in differentiation, apoptosis, and proliferation, we realize important questions remain to be addressed. In particular, the cross-talk between activated glucocorticoid receptor (GR) and GR interactome with other receptors and signaling molecules appears a field of undisclosed potentials.
At the cellular levels, some evidence suggests that glucocorticoids modulate differentiation and survival of regulatory T cells (Tregs) and tolerogenic macrophages (e.g., M2), possibly by shaping the long-term maturation of the immune system. These effects may have a favorable impact on the development of inflammatory and autoimmune diseases but, at the same time, a deleterious effect on cancer immunosurveillance and progression. Hence, the interactions between synthetic glucocorticoids and immunosuppressive/immunomodulatory biologics that are currently in use or still under investigation (e.g., anti-CD3 and IL-2 antibodies), as well as synthetic glucocorticoids and epigenetic drugs (e.g., histone deacetylase inhibitors), deserve to be investigated.
The growing awareness concerning the effects of glucocorticoids on neuroendocrine system and behavior has created an urgent need to investigate the glucocorticoid-dependent neural network shaping. The concern about the sexually dimorphic actions of glucocorticoids on neuroendocrine system and other tissues has been catching on from a theoretic point of view and soon will have an impact on the clinics. The glucocorticoid-dependent damage to the skin and the direct protection of numerous non-immune cell types from the deleterious effect of inflammation are well known, but the underlined mechanisms deserve more studies. Topical glucocorticoids, including inhalation corticosteroids (ICSs), play a crucial role in the treatment of asthma, inflammatory bowel disease (IBD) and skin diseases, but their mechanism of action and adverse effects are still under investigation. Finally, new molecules modulating the activity of GR or mimicking the effect of GR activation are investigated with interesting results.
My hope and my ambition are that this Special Issue of IJMS may summarize these issues and shed new light on some of these, thanks to the contribution and the outstanding scientific research of the best scientists working in the glucocorticoid field.
Assoc. Prof. Dr. Giuseppe Nocentini
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Genomic effects of glucocorticoids
- Non-genomic effects of glucocorticoids
- Glucocorticoid-dependent modulation of the immune cells
- Effects of glucocorticoids on differentiation and survival of Treg cells
- Effects of glucocorticoids on differentiation and survival of tolerogenic macrophages
- Glucocorticoid-dependent survival of parenchymal cells
- Effects of glucocorticoids on neurons
- New drugs binding to the glucocorticoid receptor
- Topical steroids in asthma and inflammatory bowel disease
- Combination therapy glucocorticoids/biologics
- Sexually dimorphic effects of glucocorticoids
- Adverse effects of topical steroids