Gender-Related Molecular Mechanism in Neurological Disorders

Dear Colleagues,

Sex differences represent key factors in understanding indicators of pathological mechanisms in neurological diseases. A number of relevant studies have been performed in the past with the aim of investigating how molecular differences related to sex-dependent aspects could shed some light on the aetiology and pathological mechanisms of neurological diseases. For instance, sex differences have been reported in several molecular and biochemical pathways such as oxidative stress. Oxidative stress mechanisms are reported to be higher in men than in women. Hormonal aspects have usually been considered the major drivers of sex differences in neurological diseases; however, more recently, other pathways such as post genomic or epigenomic modification have been found to have a considerable contribution.

The purpose of this Special Issue of IJMS is to explore how sex and gender issues may act in influencing the molecular pathways of neurological disorders and neurodegeneration, in order to understand the pathologies underlying neurodegenerative processes. This Special Issue will cover studies considering animal models, biochemical and/or experimental studies investigating molecular pathways, and reviews exploring molecular and pathogenic mechanisms, revealing new insights into comprehending the pathophysiological modifications associated with the effects of sex and gender on neurological diseases. The issue will highlight how pathologic processes of neurological and neurodegenerative diseases can be determined or modified by sex-dependent issues.

Dr. Paolo Ragonese
Guest Editor

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