Glycobiology of Health and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (20 March 2025) | Viewed by 5969
Special Issue Editor
Interests: glycosphingolipids; neuronal cell; glioma cell; cancer; glycosylation; gangliosides; inflammation; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Since we began to understand the genetic mechanisms underlying the generation, development, and maintenance of our bodies approximately 70 years ago, the Genome Project and the subsequent Proteomics Project have played dominant roles in the explanation of the actions of all genome products and in the understanding of the results of those interactions. Now, it seems that the majority of the processes involved in health and diseases can be explained based on genomics and proteomics.
However, it has been elucidated that many biomolecules exerting living processes undergo modification with glyco-chains. Many proteins, lipids, and even nucleic acids undergo glycosylation in various modes, depending on the biological situation, such as development, differentiation, aging, and degeneration and depending also on the environmental conditions, such as nutrition, practice, labor, temperature, moisture, toxic agents in foods, gas, and water, and also infections of foreign microorganisms. These factors include both physiological and pathological processes, and modification with glyco-chains seems to be either the mere results of the biological response or a reasonable protective reaction.
Whatever the meaning of glycosylation, various glycosylation products modify the modes of interactions, leading to diverse results in the fates of molecules, cells, organs, and tissues. The accumulation of these interactions result in the formation of our bodies, the status of our health/any diseases we experience, and our wellbeing.
Now, we are required to observe changes in glyco-chains in various situations at various sites, in order to understand glycosylation mechanisms and their regulatory systems. In particular, the following subjects are expected to be researched: 1. challenges in elucidating the expression profiles of glyco-chains in various molecules, cells, and tissues in various situations; 2. analyses of the roles of glycans involved in the interaction between cells, organelles, and bio-organisms, such as humans and parasites/bacteria/viruses; and 3. analyses of the interaction mechanisms between glycans and various ligand molecules such as lectins, leading to diverse phenotypes and cell signals. Any studies on these various aspects of glycosylation are welcome and would contribute to the progress in the field of the glycobiology of health and diseases.
Prof. Dr. Koichi Furukawa
Guest Editor
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Keywords
- sugar chains
- carbohydrate-recognizing molecules
- glycolipids
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