Next Article in Journal
Antidiabetic Therapy in the Treatment of Nonalcoholic Steatohepatitis
Next Article in Special Issue
Mechanism of Secondary Ganglioside and Lipid Accumulation in Lysosomal Disease
Previous Article in Journal
Natural Products Targeting ER Stress, and the Functional Link to Mitochondria
Previous Article in Special Issue
Ganglioside Synthesis by Plasma Membrane-Associated Sialyltransferase in Macrophages
Review

Novel Molecular Mechanisms of Gangliosides in the Nervous System Elucidated by Genetic Engineering

1
Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, 1200 Matsumoto, Kasugai, Aichi 487-8501, Japan
2
Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-0065, Japan
3
Department of Medical Technology, Chubu University College of Life and Health Sciences, 1200 Matsumoto, Kasugai, Aichi 487-8501, Japan
4
Department of Tissue Regeneration, Tokushima University Graduate School of Biomedical Sciences, 3-18-5, Kuramoto-cho, Tokushima 770-8504, Japan
5
Department of Glycooncology, Osaka International Cancer Institute, Osaka 541-8567, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(6), 1906; https://doi.org/10.3390/ijms21061906
Received: 31 January 2020 / Revised: 29 February 2020 / Accepted: 6 March 2020 / Published: 11 March 2020
(This article belongs to the Special Issue Gangliosides: Modes of Action and Cell Fates)
Acidic glycosphingolipids, i.e., gangliosides, are predominantly and consistently expressed in nervous tissues of vertebrates at high levels. Therefore, they are considered to be involved in the development and function of nervous systems. Recent studies involving genetic engineering of glycosyltransferase genes have revealed novel aspects of the roles of gangliosides in the regulation of nervous tissues. In this review, novel findings regarding ganglioside functions and their modes of action elucidated mainly by studies of gene knockout mice are summarized. In particular, the roles of gangliosides in the regulation of lipid rafts to maintain the integrity of nervous systems are reported with a focus on the roles in the regulation of neuro-inflammation and neurodegeneration via complement systems. In addition, recent advances in studies of congenital neurological disorders due to genetic mutations of ganglioside synthase genes and also in the techniques for the analysis of ganglioside functions are introduced. View Full-Text
Keywords: ganglioside; knockout; neurodegeneration; glycosphingolipid; inflammation; microdomain ganglioside; knockout; neurodegeneration; glycosphingolipid; inflammation; microdomain
Show Figures

Figure 1

MDPI and ACS Style

Furukawa, K.; Ohmi, Y.; Yesmin, F.; Tajima, O.; Kondo, Y.; Zhang, P.; Hashimoto, N.; Ohkawa, Y.; Bhuiyan, R.H.; Furukawa, K. Novel Molecular Mechanisms of Gangliosides in the Nervous System Elucidated by Genetic Engineering. Int. J. Mol. Sci. 2020, 21, 1906. https://doi.org/10.3390/ijms21061906

AMA Style

Furukawa K, Ohmi Y, Yesmin F, Tajima O, Kondo Y, Zhang P, Hashimoto N, Ohkawa Y, Bhuiyan RH, Furukawa K. Novel Molecular Mechanisms of Gangliosides in the Nervous System Elucidated by Genetic Engineering. International Journal of Molecular Sciences. 2020; 21(6):1906. https://doi.org/10.3390/ijms21061906

Chicago/Turabian Style

Furukawa, Koichi, Yuhsuke Ohmi, Farhana Yesmin, Orie Tajima, Yuji Kondo, Pu Zhang, Noboru Hashimoto, Yuki Ohkawa, Robiul H. Bhuiyan, and Keiko Furukawa. 2020. "Novel Molecular Mechanisms of Gangliosides in the Nervous System Elucidated by Genetic Engineering" International Journal of Molecular Sciences 21, no. 6: 1906. https://doi.org/10.3390/ijms21061906

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop