DNA DSB Repair, Mitochondrial Dysfunctions and Modulation Pathways after Exposure to Ionizing Radiation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 4089
Special Issue Editors
Interests: radiation damage and DNA repair; pathways to preserving mitochondrial DNA; mitochondrial dysfunction; radiation mutagenesis; anti-mutagenesis; anti-carcinogenesis; extracellular circulating DNA; NUMT pseudogenes; free radicals and antioxidants; radioprotectors und radiomitigators; aging and geroprotectors
Special Issue Information
Dear Colleagues,
We are pleased to announce the release of a Special Issue of the International Journal of Molecular Sciences on the topic of DNA DSB repair in the context of chromatin and mitochondrial dysfunctions in cells after exposure to ionizing radiation, and pathways of their modulation. We invite authors to submit your original scientific articles as well as thematic reviews.
As the results of many studies show, the induction of DNA double-strand breaks (DSB) and mitochondrial dysfunction, with increased oxidative stress, can be considered two critical events leading to cell death or the development of long-term consequences due to ionizing radiation (IR). Although there are significant achievements in this direction, additional knowledge is still required, using experimental models in vitro and in vivo. Further expansion of knowledge on these issues is of interest both for finding a means to reduce radiation damage and for improving the effectiveness of radiation therapy for cancer. Nuclear–mitochondrial signaling communications play an important role in cell survival and death. However, research in this aspect also requires further development after radiation exposure. Structural and functional disorders in mitochondria induced by IR lead to the development of a whole complex of effects at the level of cells and the whole organism. The mechanisms of repair of complex cluster DNA damage in mammalian cells induced by heavy densely ionizing particles have not yet been sufficiently elucidated. It is important to develop research to elucidate the repair of cluster DSB of DNA in the context of chromatin. The search for ways to modulate DSB of DNA repair and mitochondrial dysfunction, as well as studies on mitochondria-targeted radiomitigators, also remain very relevant.
Prof. Azhub Gaziev
Prof. Dr. Krasavin Evgeniy
Guest Editors
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Keywords
- radiation damage and DNA repair
- cluster DSB of DNA
- pathways to preserve mitochondrial DNA (mtDNA)
- mitochondrial dysfunction
- mtDNA mutagenesis
- mitochondrial ROS
- degradation mtDNA
- extracellular circulating DNA
- mitophagy and mitogenesis
- radioprotectors and radiomitigators
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