Integrative Physiology of the Circadian Clock

Dear Colleagues,

All the physiological systems have to integrate to provide for the normal functioning of an organism. However, the circadian clock system is a likely champion of integrative physiology. This starts from the molecular level of the clock, forming feedback and feed-forward loops, and is then reflected in the mechanisms synchronizing individual cellular clocks on the local level of tissues and organs. These numerous cellular clocks are then supervised by yet another integrative level of the master clock, assuring an internal synergy of all the physiological systems. Finally, integration into the clock system of the external time cues allows an organism to anticipate and adapt to the periodically changing environment. This issue of IJMS aims to provide a comprehensive view of novel discoveries on the mechanisms of this complex and dynamic process of time keeping, and its role in normal physiology and pathological conditions that are relevant to human health.

Dr. Irina Zhdanova
Guest Editor

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