Special Issue "Molecular Recognition of Carbohydrates"
Deadline for manuscript submissions: closed (31 December 2017).
Interests: carbohydrates; molecular recognition; NMR
2. Ikerbasque, Basque Foundation for Science, Maria López de Haro 3, 48013 Bilbao, Spain
Interests: molecular recognition towards drug and molecular probe design; NMR; molecular recognition; glycans
Carbohydrates are among the most ubiquitous and complex types of biomolecules in nature. Although they are secondary gene products, and look like very simple molecules in terms of chemical functional groups (polyhydroxylated molecules with a formal carbonyl group), they support an astonishing capacity of carrying biological information, conforming to the so-called “glycan code”. The possibilities of diversity for their oligomeric structures (stereochemistry, branching, and secondary modifications) overwhelm those exerted by the other two key biomolecules, nucleic acids and proteins.
Carbohydrates play a very important role in intra- and intercellular molecular recognition events that trigger a variety of physiological and pathological events (glycoprotein fate and stability, fertilization, immunological responses, inflammation, cell defense or infection, cancer, etc).
Therefore, knowledge of their precise chemical structure with the maximum resolution possible, and access to key information on their interaction processes with different entities, such as lectins, enzymes, and antibodies, are essential for the understanding of many vital processes, as well as for opening the possibility of their modulation. To this aim, multidisciplinary research strategies (design and synthesis of natural glycans and their glycomimetics, development of glycoarrays and glyconanomaterials, physico-chemical characterization, NMR and X-ray structural determination, molecular modeling, biotechnological production, and cell biology protocols) are in continuous expansion in the field of glycosciences.
Prof. Francisco Javier Cañada
Prof. Jesus Jimenez-Barbero
Manuscript Submission Information
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- Molecular recognition
- Carbohydrate-protein interactions
- Carbohydrate structure
- Carbohydrate synthesis
- Glyconanostructures (glyconanoparticles, glycan dendrimers)