Special Issue "Brain-Derived Neurotrophic Factor 2020"
Deadline for manuscript submissions: closed (31 October 2020).
Special Issues and Collections in MDPI journals
This Special Issue is a continuation of our previous Special Issue “Brain-Derived Neurotrophic Factor 2018”. (https://www.mdpi.com/journal/ijms/special_issues/bdnf_2018)
This Special Issue, “Brain-Derived Neurotrophic Factor”, will cover a selection of recent research topics and current review articles in the field of mechanism, expression, function and neuroprotective effects of Brain-Derived Neurotrophic Factor in the central nerve and peripheral nerve system. Experimental papers, up-to-date review articles, and commentaries are all welcome.
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors. It acts on certain neurons of the central nervous system and the peripheral nervous system, helping to support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses. BDNF plays a significant role in neuroprotective effects. BDNF can promote protective pathways and inhibit damaging pathways that contribute to the brain’s neurogenic response by enhancing cell survival. This becomes especially evident following suppression of tropomyosin-related kinase B (TrkB) activity. BDNF recently was found to enhance survival and neuronal differentiation of human neural precursor cells in rat models of auditory neuronal damage. BDNF from bone marrow-derived cells promoted post-injury repair of sciatic nerve in mice. Therefore, BDNF would represent an attractive treatment modality for nerve injuries in addition to peripheral neuropathic disorders, such as diabetes mellitus.
Prof. Dr. Kenji Hashimoto
Dr. Abbas F. Sadikot
Prof. Dr. Guiting Lin
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Brain-Derived Neurotrophic Factor (BDNF)
- Nerve regeneration
- Survival and neuronal differentiation
- Central nerve system
- Peripheral nerve system
- Cellular signaling transduction
- Tropomyosin-related kinase B (TrkB)
- Clinical trials