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Cytokines in Inflammation and Health
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Cytokines in Inflammation and Health

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 3093

Special Issue Editor

Dr. Jörg Hermann Fritz

E-Mail Website
Guest Editor
Department of Microbiology and Immunology, McGill Research Center on Complex Traits (MRCCT), McGill University, Montreal, QC H3G 0B1, Canada
Interests: mucosal immunology; chronic disease; infectious disease biology; vaccinology; immunotherapy; type 2 immunopathologies; innate immunity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cytokines are critical for the development of protective immune responses against pathogens and cancer. While a lack of certain cytokines or the inability to respond to them can be detrimental to health (e.g., immune deficiency diseases), their excessive production and uncontrolled activities can lead to inflammatory diseases (e.g., asthma, arthritis, inflammatory bowel disease and COVID-19 complications) and contribute to the development of metabolic disorders. It has been firmly established that persistent inflammatory cytokine production promotes the development of a variety of malignancies, including melanoma, colorectal, liver and pancreatic cancer. Finally, it is increasingly clear that inflammatory cytokines secreted by senescent cells contribute to aging and age-associated diseases. Therefore, cytokines are a double-edged sword that can be therapeutically manipulated to treat a broad range of human diseases. Hence, I invite you to contribute the latest research findings or a review article to this Special Issue on “Cytokines in Inflammation and Health”.

Dr. Jörg Hermann Fritz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cytokines
  • inflammation
  • ageing
  • cancer
  • obesity
  • novel therapies

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Published Papers (3 papers)

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Research

13 pages, 2479 KiB  
Article
Significant Associations Between Blood Cell Counts and Plasma Cytokines, Chemokines, and Growth Factors
by Lars B. Eriksson, Mats B. Eriksson, Torsten Gordh and Anders O. Larsson
Int. J. Mol. Sci. 2025, 26(9), 4065; https://doi.org/10.3390/ijms26094065 - 25 Apr 2025
Viewed by 281
Abstract
The cytokine network plays a crucial role in regulating immune responses and facilitating intercellular communication. Cytokines are essential in numerous physiological and pathological processes. This study aimed to investigate associations between blood cell counts and a broad range of cytokines, chemokines, and growth [...] Read more.
The cytokine network plays a crucial role in regulating immune responses and facilitating intercellular communication. Cytokines are essential in numerous physiological and pathological processes. This study aimed to investigate associations between blood cell counts and a broad range of cytokines, chemokines, and growth factors. We included one hundred and sixty-five essentially healthy individuals in this study, which was approved by the Swedish Ethical Review Authority (Dnr 2015/378) and registered in EudraCT (2014-004235-39). Blood samples were collected for blood cell counts and analysis of cytokines, chemokines, and growth factors using the Proseek Multiplex Inflammation kit, Olink Bioscience, Uppsala, Sweden. Correlations between the different markers were calculated using Spearman rank correlations, adjusted for multiplicity and for multiple testing, with a significance threshold of p < 0.05. There were significant associations between platelet count and 23 cytokines, between white blood cell count and 8 cytokines, and between erythrocyte volume fractions and 19 cytokines. IL-6 had a central role within the cytokine network associated with platelets and was also associated with white blood cells and neutrophil cells. These findings emphasize the integrated nature of immune and hematological responses, where blood cell parameters are associated with systemic cytokine activity. The observed intercytokine associations, including cross-family interactions, may help to highlight regulatory pathways, providing potential targets for biomarker development and therapeutic intervention in immune-mediated conditions. Full article
(This article belongs to the Special Issue Cytokines in Inflammation and Health)
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17 pages, 3573 KiB  
Article
The Role of TNF Receptor-Associated Factor 5 in the Formation of Germinal Centers by B Cells During the Primary Phase of the Immune Response in Mice
by Mari Hikosaka-Kuniishi, Chieri Iwata, Yusuke Ozawa, Sayaka Ogawara, Tomomi Wakaizumi, Riho Itaya, Ren Sunakawa, Ayaka Sato, Hodaka Nagai, Masashi Morita and Takanori So
Int. J. Mol. Sci. 2024, 25(22), 12331; https://doi.org/10.3390/ijms252212331 - 17 Nov 2024
Cited by 1 | Viewed by 1129
Abstract
TNF receptor-associated factors (TRAFs) function as intracellular adaptor proteins utilized by members of the TNF receptor superfamily, such as CD40. Among the TRAF family proteins, TRAF5 has been identified as a potential regulator of CD40. However, it remains unclear whether TRAF5 regulates the [...] Read more.
TNF receptor-associated factors (TRAFs) function as intracellular adaptor proteins utilized by members of the TNF receptor superfamily, such as CD40. Among the TRAF family proteins, TRAF5 has been identified as a potential regulator of CD40. However, it remains unclear whether TRAF5 regulates the generation of germinal center (GC) B cells and antigen-specific antibody production in the T-dependent (TD) immune response. TRAF5-deficient (Traf5−/−) and TRAF5-sufficient (Traf5+/+) mice were immunized in the footpad with 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin (TNP-KLH) and complete Freund’s adjuvant (CFA). We found that GC B cell generation and antigen-specific IgM and IgG1 production were significantly impaired in Traf5−/− mice compared to Traf5+/+ mice. The expression levels of CD40-target genes Fas and Lta, which are involved in GC formation, were significantly decreased in B220+ cells isolated from immunized Traf5−/− mice. Traf5−/− B cells showed decreased antibody production, proliferation, and induction of CD40-target genes Tnfaip3, Tnfsf4, and Cd80 in response to agonistic Fc-CD40L protein in vitro. Furthermore, administration of TNP-KLH and Fc-CD40L to Traf5−/− mice resulted in a severe loss of GC B cell development. These results highlight the crucial role of TRAF5 in driving CD40-mediated TD immune response in vivo. Full article
(This article belongs to the Special Issue Cytokines in Inflammation and Health)
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15 pages, 1610 KiB  
Article
Levels of Plasma Endothelin-1, Circulating Endothelial Cells, Endothelial Progenitor Cells, and Cytokines after Cardiopulmonary Bypass in Children with Congenital Heart Disease: Role of Endothelin-1 Regulation
by Angélica Rangel-López, Héctor González-Cabello, María Eugenia Paniagua-Medina, Ricardo López-Romero, Lourdes Andrea Arriaga-Pizano, Miguel Lozano-Ramírez, Juan José Pérez-Barragán, Horacio Márquez-González, Dulce María López-Sánchez, Minerva Mata-Rocha, Ramon Paniagua-Sierra, Abraham Majluf-Cruz, Dina Villanueva-García, Sergio Zavala-Vega, Juan Carlos Núñez-Enríquez, Juan Manuel Mejía-Aranguré and José Arellano-Galindo
Int. J. Mol. Sci. 2024, 25(16), 8895; https://doi.org/10.3390/ijms25168895 - 15 Aug 2024
Viewed by 1200
Abstract
Congenital heart disease (CHD) can be complicated by pulmonary arterial hypertension (PAH). Cardiopulmonary bypass (CPB) for corrective surgery may cause endothelial dysfunction, involving endothelin-1 (ET-1), circulating endothelial cells (CECs), and endothelial progenitor cells (EPCs). These markers can gauge disease severity, but their levels [...] Read more.
Congenital heart disease (CHD) can be complicated by pulmonary arterial hypertension (PAH). Cardiopulmonary bypass (CPB) for corrective surgery may cause endothelial dysfunction, involving endothelin-1 (ET-1), circulating endothelial cells (CECs), and endothelial progenitor cells (EPCs). These markers can gauge disease severity, but their levels in children’s peripheral blood still lack consensus for prognostic value. The aim of our study was to investigate changes in ET-1, cytokines, and the absolute numbers (Ɲ) of CECs and EPCs in children 24 h before and 48 h after CPB surgery to identify high-risk patients of complications. A cohort of 56 children was included: 41 cases with CHD-PAH (22 with high pulmonary flow and 19 with low pulmonary flow) and 15 control cases. We observed that Ɲ-CECs increased in both CHD groups and that Ɲ-EPCs decreased in the immediate post-surgical period, and there was a strong negative correlation between ET-1 and CEC before surgery, along with significant changes in ET-1, IL8, IL6, and CEC levels. Our findings support the understanding of endothelial cell precursors’ role in endogenous repair and contribute to knowledge about endothelial dysfunction in CHD. Full article
(This article belongs to the Special Issue Cytokines in Inflammation and Health)
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