Molecular Mechanism of DNA Replication and Repair, 3rd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 2949
Special Issue Editors
Interests: DNA repair; DNA nuclease; DNA helicase; archaea; HR
Special Issues, Collections and Topics in MDPI journals
Interests: DNA replication and repair; genome stability; archaea
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
During cell division, the replisome machinery is capable of quickly and accurately copying billions of DNA bases in order to maintain genome integrity and prevent diseases. Nevertheless, it can produce errors, particularly when the DNA is damaged. dsDNA is a stable, chemically inert molecule that is continuously subjected to a variety of exogenous and endogenous insults throughout the cell cycle. Unrepaired or misrepaired DNA lesions may cause mutations or chromosomal damage and, ultimately, abnormalities, including oncogenic transformation. For the maintenance of genomic stability, organisms have developed signal pathways that give rise to a DNA damage response (DDR). This mechanism is characterized by its capability to tolerate DNA damage and structural impediments during DNA synthesis; thus, it replicates fork progression and stability in the presence of blocking structures or DNA lesions. Malfunctioning DDR can cause fork arrest and eventually fork collapse, leading to the formation of DNA double-strand breaks.
This Special Issue of IJMS aims to expand our current understanding of molecular and cellular mechanisms of DNA replication and repair. We want to offer a platform for high-quality publications on various aspects of DNA replication and repair research. Bringing together different aspects into one Special Issue, hopefully, will trigger the development of new therapies in human diseases.
Dr. Mariarita De Felice
Dr. Mariarosaria De Falco
Guest Editors
Manuscript Submission Information
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Keywords
- genome stability
- DNA repair
- DNA replication
- DDR
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