Topic Editors

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

Advances in Natural Products and Phytochemicals in Cancer Prevention and Therapeutics

Abstract submission deadline
13 November 2024
Manuscript submission deadline
13 February 2025
Viewed by
10496

Topic Information

Dear Colleagues,

Natural products, or phytochemicals, generally refer to as compounds that are exclusive to essential nutrients that have specific biological activities in humans. Studies have shown that natural phytochemicals derived from certain plants have the ability to prevent carcinogenesis. Therefore, new active compounds responsible for the anti-cancer characteristics of dietary plants, and new active compounds that exert novel anti-carcinogenesis functions are important topics in cancer research. We invite researchers to contribute original and review articles regarding the relationships between natural products, phytochemicals and cancers, including the discovery of novel anti-cancer phytochemicals, signalling pathways, and phytochemical signalling molecules for potential cancer treatment strategies. We are pleased to invite you to our Special Issue “Advances in Natural Products and Phytochemicals in Cancer Prevention and Therapeutics”. We look forward to receiving your contributions.

Prof. Dr. Shun-Fa Yang
Dr. Ming-Hsien Chien
Topic Editors

Keywords

  • natural compound
  • phytochemicals
  • chemoprevention
  • anti-cancer
  • flavonoids
  • apoptosis
  • metastasis
  • autophagy
  • MMP

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Antioxidants
antioxidants
7.0 10.6 2012 13.9 Days CHF 2900 Submit
Biomolecules
biomolecules
5.5 9.4 2011 16.9 Days CHF 2700 Submit
Cancers
cancers
5.2 8.0 2009 17.9 Days CHF 2900 Submit
Cells
cells
6.0 9.9 2012 16.6 Days CHF 2700 Submit
International Journal of Molecular Sciences
ijms
5.6 8.1 2000 16.3 Days CHF 2900 Submit
Pathogens
pathogens
3.7 6.4 2012 16.4 Days CHF 2700 Submit

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Published Papers (8 papers)

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21 pages, 1525 KiB  
Review
Research on the Medicinal Chemistry and Pharmacology of Taxus × media
by Xinyu Gao, Ni Zhang and Weidong Xie
Int. J. Mol. Sci. 2024, 25(11), 5756; https://doi.org/10.3390/ijms25115756 - 25 May 2024
Viewed by 263
Abstract
Taxus × media, belonging to the genus Taxus of the Taxaceae family, is a unique hybrid plant derived from a natural crossbreeding between Taxus cuspidata and Taxus baccata. This distinctive hybrid variety inherits the superior traits of its parental species, exhibiting [...] Read more.
Taxus × media, belonging to the genus Taxus of the Taxaceae family, is a unique hybrid plant derived from a natural crossbreeding between Taxus cuspidata and Taxus baccata. This distinctive hybrid variety inherits the superior traits of its parental species, exhibiting significant biological and medicinal values. This paper comprehensively analyzes Taxus × media from multiple dimensions, including its cultivation overview, chemical composition, and multifaceted applications in the medical field. In terms of chemical constituents, this study delves into the bioactive components abundant in Taxus × media and their pharmacological activities, highlighting the importance and value of these components, including paclitaxel, as the lead compounds in traditional medicine and modern drug development. Regarding its medicinal value, the article primarily discusses the potential applications of Taxus × media in combating tumors, antibacterial, anti-inflammatory, and antioxidant activities, and treating diabetes. By synthesizing clinical research and experimental data, the paper elucidates the potential and mechanisms of its primary active components in preventing and treating these diseases. In conclusion, Taxus × media demonstrates its unique value in biological research and tremendous potential in drug development. Full article
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18 pages, 1967 KiB  
Review
Review of the Potential Role of Ascorbate in the Prevention and Treatment of Gynecological Cancers
by Xiaochang Shen, Jiandong Wang, Boer Deng, Ziyi Zhao, Shuning Chen, Weimin Kong, Chunxiao Zhou and Victoria Bae-Jump
Antioxidants 2024, 13(5), 617; https://doi.org/10.3390/antiox13050617 - 19 May 2024
Viewed by 728
Abstract
Ascorbate (vitamin C) is an essential vitamin for the human body and participates in various physiological processes as an important coenzyme and antioxidant. Furthermore, the role of ascorbate in the prevention and treatment of cancer including gynecological cancer has gained much more interest [...] Read more.
Ascorbate (vitamin C) is an essential vitamin for the human body and participates in various physiological processes as an important coenzyme and antioxidant. Furthermore, the role of ascorbate in the prevention and treatment of cancer including gynecological cancer has gained much more interest recently. The bioavailability and certain biological functions of ascorbate are distinct in males versus females due to differences in lean body mass, sex hormones, and lifestyle factors. Despite epidemiological evidence that ascorbate-rich foods and ascorbate plasma concentrations are inversely related to cancer risk, ascorbate has not demonstrated a significant protective effect in patients with gynecological cancers. Adequate ascorbate intake may have the potential to reduce the risk of human papillomavirus (HPV) infection and high-risk HPV persistence status. High-dose ascorbate exerts antitumor activity and synergizes with chemotherapeutic agents in preclinical cancer models of gynecological cancer. In this review, we provide evidence for the biological activity of ascorbate in females and discuss the potential role of ascorbate in the prevention and treatment of ovarian, endometrial, and cervical cancers. Full article
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20 pages, 3263 KiB  
Article
Defining a Water-Soluble Formulation of Arachidonic Acid as a Novel Ferroptosis Inducer in Cancer Cells
by Zoe I. Day, Alyce J. Mayfosh, Amy A. Baxter, Scott A. Williams, Joanne M. Hildebrand, Thomas F. Rau, Ivan K. H. Poon and Mark D. Hulett
Biomolecules 2024, 14(5), 555; https://doi.org/10.3390/biom14050555 - 4 May 2024
Viewed by 906
Abstract
Here, we describe GS-9, a novel water-soluble fatty acid-based formulation comprising L-lysine and arachidonic acid, that we have shown to induce ferroptosis. GS-9 forms vesicle-like structures in solution and mediates lipid peroxidation, as evidenced by increased C11-BODIPY fluorescence and an accumulation of toxic [...] Read more.
Here, we describe GS-9, a novel water-soluble fatty acid-based formulation comprising L-lysine and arachidonic acid, that we have shown to induce ferroptosis. GS-9 forms vesicle-like structures in solution and mediates lipid peroxidation, as evidenced by increased C11-BODIPY fluorescence and an accumulation of toxic malondialdehyde, a downstream product of lipid peroxidation. Ferroptosis inhibitors counteracted GS-9-induced cell death, whereas caspase 3 and 7 or MLKL knock-out cell lines are resistant to GS-9-induced cell death, eliminating other cell death processes such as apoptosis and necroptosis as the mechanism of action of GS-9. We also demonstrate that through their role of sequestering fatty acids, lipid droplets play a protective role against GS-9-induced ferroptosis, as inhibition of lipid droplet biogenesis enhanced GS-9 cytotoxicity. In addition, Fatty Acid Transport Protein 2 was implicated in GS-9 uptake. Overall, this study identifies and characterises the mechanism of GS-9 as a ferroptosis inducer. This formulation of arachidonic acid offers a novel tool for investigating and manipulating ferroptosis in various cellular and anti-cancer contexts. Full article
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15 pages, 4247 KiB  
Article
In Vitro and In Vivo Imaging-Based Evaluation of Doxorubicin Anticancer Treatment in Combination with the Herbal Medicine Black Cohosh
by Agata Płoska, Marcin Wozniak, Jamila Hedhli, Christian J. Konopka, Antonios Skondras, Sarah Matatov, Andrew Stawarz, Sarah Schuh, Andrzej Czerwinski, Lawrence W. Dobrucki, Leszek Kalinowski and Iwona T. Dobrucki
Int. J. Mol. Sci. 2023, 24(24), 17506; https://doi.org/10.3390/ijms242417506 - 15 Dec 2023
Viewed by 902
Abstract
As a substitution for hormone replacement therapy, many breast cancer patients use black cohosh (BC) extracts in combination with doxorubicin (DOX)-based chemotherapy. In this study, we evaluated the viability and survival of BC- and DOX-treated MCF-7 cells. A preclinical model of MCF-7 xenografts [...] Read more.
As a substitution for hormone replacement therapy, many breast cancer patients use black cohosh (BC) extracts in combination with doxorubicin (DOX)-based chemotherapy. In this study, we evaluated the viability and survival of BC- and DOX-treated MCF-7 cells. A preclinical model of MCF-7 xenografts was used to determine the influence of BC and DOX administration on tumor growth and metabolism. The number of apoptotic cells after incubation with both DOX and BC was significantly increased (~100%) compared to the control. Treatment with DOX altered the potential of MCF-7 cells to form colonies; however, coincubation with BC did not affect this process. In vivo, PET-CT imaging showed that combined treatment of DOX and BC induced a significant reduction in both metabolic activity (29%) and angiogenesis (32%). Both DOX and BC treatments inhibited tumor growth by 20% and 12%, respectively, and combined by 57%, vs. control. We successfully demonstrated that BC increases cytotoxic effects of DOX, resulting in a significant reduction in tumor size. Further studies regarding drug transport and tumor growth biomarkers are necessary to establish the underlying mechanism and potential clinical use of BC in breast cancer patients. Full article
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14 pages, 3471 KiB  
Article
Hypericin-Based Photodynamic Therapy Displays Higher Selectivity and Phototoxicity towards Melanoma and Squamous Cell Cancer Compared to Normal Keratinocytes In Vitro
by Marta Woźniak and Martyna Nowak-Perlak
Int. J. Mol. Sci. 2023, 24(23), 16897; https://doi.org/10.3390/ijms242316897 - 29 Nov 2023
Cited by 1 | Viewed by 831
Abstract
The aim of this study was to explore the potential of hypericin, a naturally occurring photosensi-tizer, for photodynamic therapy (PDT) in skin cancer, investigating its phototoxic effects and mechanisms of action in cancer cells compared to normal skin keratinocytes, squamous cell cancer (SCC-25) [...] Read more.
The aim of this study was to explore the potential of hypericin, a naturally occurring photosensi-tizer, for photodynamic therapy (PDT) in skin cancer, investigating its phototoxic effects and mechanisms of action in cancer cells compared to normal skin keratinocytes, squamous cell cancer (SCC-25) cells and melanoma (MUG-Mel2) cells. Hypericin was applied at concentrations ranging from 0.1–40 μM to HaCaT, SCC-25, and MUG-Mel2 cells. After 24 h of incubation, the cells were exposed to orange light at 3.6 J/cm2 or 7.2 J/cm2. Phototoxicity was assessed using MTT and SRB tests. Cellular uptake was measured by flow cytometry. Apoptosis-positive cells were estimated through TUNEL for apoptotic bodies’ visualization. Hypericin exhibited a higher phototoxic reaction in cancer cells compared to normal keratinocytes after irradiation. Cancer cells demonstrated increased and selective uptake of hypericin. Apoptosis was observed in SCC-25 and MUG-Mel2 cells following PDT. Our findings suggest that hypericin-based PDT is a promising and less invasive approach for treating skin cancer. The higher phototoxic reaction, selective uptake by cancer cells, and observed proapoptotic properties support the promising role of hypericin-based PDT in skin cancer treatment. Full article
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18 pages, 4537 KiB  
Article
Pllans−II: Unveiling the Action Mechanism of a Promising Chemotherapeutic Agent Targeting Cervical Cancer Cell Adhesion and Survival Pathways
by Alejandro Montoya-Gómez, Fiorella Tonello, Barbara Spolaore, Maria Lina Massimino, Leonel Montealegre-Sánchez, Andrés Castillo, Nelson Rivera Franco, María José Sevilla-Sánchez, Luis Manuel Solano-Redondo, Mildrey Mosquera-Escudero and Eliécer Jiménez-Charris
Cells 2023, 12(23), 2715; https://doi.org/10.3390/cells12232715 - 27 Nov 2023
Viewed by 983
Abstract
Despite advances in chemotherapeutic drugs used against cervical cancer, available chemotherapy treatments adversely affect the patient’s quality of life. For this reason, new molecules from natural sources with antitumor potential and few side effects are required. In previous research, Pllans−II, a phospholipase [...] Read more.
Despite advances in chemotherapeutic drugs used against cervical cancer, available chemotherapy treatments adversely affect the patient’s quality of life. For this reason, new molecules from natural sources with antitumor potential and few side effects are required. In previous research, Pllans−II, a phospholipase A2 type-Asp49 from Porthidium lansbergii lansbergii snake venom, has shown selective attack against the HeLa and Ca Ski cervical cancer cell lines. This work suggests that the cytotoxic effect generated by Pllans−II on HeLa cells is triggered without affecting the integrity of the cytoplasmic membrane or depolarizing the mitochondrial membranes. The results allow us to establish that cell death in HeLa is related to the junction blockage between α5β1 integrins and fibronectin of the extracellular matrix. Pllans−II reduces the cells’ ability of adhesion and affects survival and proliferation pathways mediated by intracellular communication with the external environment. Our findings confirmed Pllans−II as a potential prototype for developing a selective chemotherapeutic drug against cervical cancer. Full article
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12 pages, 2465 KiB  
Article
New Copper-Based Metallodrugs with Anti-Invasive Capacity
by Alessia Garufi, Francesca Scarpelli, Loredana Ricciardi, Iolinda Aiello, Gabriella D’Orazi and Alessandra Crispini
Biomolecules 2023, 13(10), 1489; https://doi.org/10.3390/biom13101489 - 7 Oct 2023
Viewed by 1485
Abstract
While metal-based complexes are deeply investigated as anticancer chemotherapeutic drugs, fewer studies are devoted to their anti-invasive activity. Herein, two copper (Cu)(II) tropolone derivatives, [Cu(Trop)Cl] and [Cu(Trop)Sac], both containing the N,N-chelated 4,4′-bishydroxymethyl-2,2′-bipyridne ligand, were evaluated for their anticancer and anti-invasive properties. RKO (RKO-ctr) [...] Read more.
While metal-based complexes are deeply investigated as anticancer chemotherapeutic drugs, fewer studies are devoted to their anti-invasive activity. Herein, two copper (Cu)(II) tropolone derivatives, [Cu(Trop)Cl] and [Cu(Trop)Sac], both containing the N,N-chelated 4,4′-bishydroxymethyl-2,2′-bipyridne ligand, were evaluated for their anticancer and anti-invasive properties. RKO (RKO-ctr) colon cancer cells and their derivatives undergoing stable small interference (si) RNA for HIPK2 protein (RKO-siHIPK2) with acquisition of pro-invasive capacity were used. The results demonstrate that while [Cu(Trop)Sac] did not show cytotoxic activity, [Cu(Trop)Cl] induced cell death in both RKO-ctr and RKO-siHIPK2 cells, indicating that structural changes on substituting the coordinated chloride ligand with saccharine (Sac) could be a key factor in suppressing mechanisms of cellular death. On the other hand, both [Cu(Trop)Sac] and [Cu(Trop)Cl] complexes counteracted RKO-siHIPK2 cell migration in the wound healing assay. The synergic effect exerted by the concomitant presence of both tropolone and saccharin ligands in [Cu(Trop)Sac] was also supported by its significant inhibition of RKO-siHIPK2 cell migration compared to the free Sac ligand. These data suggest that the two Cu(II) tropolone derivatives are also interesting candidates to be further tested in in vivo models as an anti-invasive tumor strategy. Full article
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36 pages, 4927 KiB  
Review
Potential Role of Natural Antioxidant Products in Oncological Diseases
by Pasquale Marino, Giacomo Pepe, Manuela Giovanna Basilicata, Vincenzo Vestuto, Stefania Marzocco, Giuseppina Autore, Alfredo Procino, Isabel Maria Gomez-Monterrey, Michele Manfra and Pietro Campiglia
Antioxidants 2023, 12(3), 704; https://doi.org/10.3390/antiox12030704 - 12 Mar 2023
Cited by 18 | Viewed by 3342
Abstract
Nutrition has a significant effect and a crucial role in disease prevention. Low consumption of fruit and vegetables and a sedentary lifestyle are closely related with the onset and development of many types of cancer. Recently, nutraceuticals have gained much attention in cancer [...] Read more.
Nutrition has a significant effect and a crucial role in disease prevention. Low consumption of fruit and vegetables and a sedentary lifestyle are closely related with the onset and development of many types of cancer. Recently, nutraceuticals have gained much attention in cancer research due to their pleiotropic effects and relatively non-toxic behavior. In fact, although in the past there have been conflicting results on the role of some antioxidant compounds as allies against cancer, numerous recent clinical studies highlight the efficacy of dietary phytochemicals in the prevention and treatment of cancer. However, further investigation is necessary to gain a deeper understanding of the potential anticancer capacities of dietary phytochemicals as well as the mechanisms of their action. Therefore, this review examined the current literature on the key properties of the bioactive components present in the diet, such as carotenoids, polyphenols, and antioxidant compounds, as well as their use in cancer therapy. The review focused on potential chemopreventive properties, evaluating their synergistic effects with anticancer drugs and, consequently, the side effects associated with current cancer treatments. Full article
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