Special Issue "The World of Transglutaminases: From Basic Biological and Medical Research to Applied Sciences"
Deadline for manuscript submissions: 20 August 2020.
Interests: tissue transglutaminase (tTG); anti-tTG antibodies and gliadin peptides in celiac disease; effects of pollutants; chemicals and bioactive compounds in cell and animal models
Interests: transglutaminase and anti-tTG in celiac disease; interplay between transglutaminase and gliadin peptides in celiac disease; modulation of cell functions by environmental polluttants; phosphoproteomics; miRNA
Interests: anti-tissue transglutaminase and angiogenesis in celiac disease; modulation of tTG function by autoantibodies; cell stress and human diseases; TBX1 gene function in angiogenesis and lymphangiogenesis in mouse models; molecular mechanisms of bioactive compounds from plants
Transglutaminases are important protein-modifying enzymes that are distributed in all the kingdoms of life. Post-translational modifications catalyzed by these enzymes produce stable networks in the extracellular matrix, in body fluids, and inside cells, thus contributing to the regulation of many aspects of cell life and death. Besides the cross-linking function, other enzymatic reactions and non-enzymatic functions can be attributed to some members of the family. In this regard, the ubiquitous multi-functional tissue transglutaminase has been nicknamed "the bete noire" of the family or "a molecular swiss army knife". Evidence on the involvement of transglutaminases in human diseases, such as cancer, fibrosis, and neurodegenerative and autoimmune diseases, is rapidly increasing. On the other hand, transglutaminases have been successfully employed as biotechnological tools in several industrial fields.
The aim of this Special Issue is to collect original and review articles on all aspects of research on the transglutaminases family, from basic research to biomedical and biotechnological applications.
Suggested topics include, but are not limited to:
- transglutaminases in bacteria, plants, and other lower, non-mammalian organisms;
- the discovery of novel transglutaminases;
- mammalian transglutaminases: new functions for old enzymes;
- the thousand faces of the tissue transglutaminase;
- transglutaminases in human diseases;
- transglutaminases as therapeutic targets; and
- transglutaminases as biotechnological tools.
Prof. Ivana Caputo
Dr. Gaetana Paolella
Dr. Stefania Martucciello
Manuscript Submission Information
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