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Tight Junctions in Cell Proliferation

Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI 48105, USA
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(23), 5972;
Received: 1 November 2019 / Revised: 22 November 2019 / Accepted: 22 November 2019 / Published: 27 November 2019
(This article belongs to the Special Issue The Tight Junction and Its Proteins: More Than Just a Barrier)
Tight junction (TJ) proteins form a continuous intercellular network creating a barrier with selective regulation of water, ion, and solutes across endothelial, epithelial, and glial tissues. TJ proteins include the claudin family that confers barrier properties, members of the MARVEL family that contribute to barrier regulation, and JAM molecules, which regulate junction organization and diapedesis. In addition, the membrane-associated proteins such as MAGUK family members, i.e., zonula occludens, form the scaffold linking the transmembrane proteins to both cell signaling molecules and the cytoskeleton. Most studies of TJ have focused on the contribution to cell-cell adhesion and tissue barrier properties. However, recent studies reveal that, similar to adherens junction proteins, TJ proteins contribute to the control of cell proliferation. In this review, we will summarize and discuss the specific role of TJ proteins in the control of epithelial and endothelial cell proliferation. In some cases, the TJ proteins act as a reservoir of critical cell cycle modulators, by binding and regulating their nuclear access, while in other cases, junctional proteins are located at cellular organelles, regulating transcription and proliferation. Collectively, these studies reveal that TJ proteins contribute to the control of cell proliferation and differentiation required for forming and maintaining a tissue barrier. View Full-Text
Keywords: tight junctions; cell growth; epithelia; endothelia; proliferation; migration tight junctions; cell growth; epithelia; endothelia; proliferation; migration
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MDPI and ACS Style

Díaz-Coránguez, M.; Liu, X.; Antonetti, D.A. Tight Junctions in Cell Proliferation. Int. J. Mol. Sci. 2019, 20, 5972.

AMA Style

Díaz-Coránguez M, Liu X, Antonetti DA. Tight Junctions in Cell Proliferation. International Journal of Molecular Sciences. 2019; 20(23):5972.

Chicago/Turabian Style

Díaz-Coránguez, Mónica, Xuwen Liu, and David A. Antonetti. 2019. "Tight Junctions in Cell Proliferation" International Journal of Molecular Sciences 20, no. 23: 5972.

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