Venous Thromboembolism, Coagulation, Metabolism and Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (30 October 2022) | Viewed by 4477
Special Issue Editors
2. ProMISE Department, University of Palermo, Palermo, Italy
Interests: ischemic stroke in diabetes; diabetic foot; Anderson-Fabry disease; cytokines
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Despite advances in research, venous thromboembolism (VTE) continues to be a significant burden for public health.A large body of literature has confirmed the link between VTE and cancer. However, the specific mechanisms leading to abnormalities in Virchow’s triad in cancer patients, particularly the effect on the host haemostatic system to promote the prothrombotic state, are not well understood. They may be tumour-specific, as different cancer types have varying risk rates for cancer-associated thrombosis. An increased risk of VTE has also been observed in metabolic disorders such as diabetes mellitus or metabolic syndrome, but the exact pathophysiological process underlying this association is still unclear.The application of metabolomics profiling in the area of vascular diseases may become a turning point in early diagnosis and patient management.The term ‘metabolomics’ refers to the comprehensive and systematic profiling of all low-molecular-weight compounds which are intermediate or final products of metabolism (e.g., carnitine, phenylalanine, 3-hydroxybutarate and many others) generated as a product of biochemical and physiological processes in the body and present in differential abundance in biofluids, cells and tissues. Despite the latest discoveries we still do not understand the mechanisms and pathways responsible for the occurrence of the observed alterations.This Special Issue attempts to explore the recent advances in venous thromboembolism.
This Special Issue welcomes original research and review papers that further clarify the link between VTE, cancer, metabolic alterations and the aspects concerning the metabolomics of VTE.
Prof. Dr. Antonino Tuttolomondo
Dr. Vittoriano Della Corte
Guest Editors
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