T Lymphocytes Biology, Pathogenesis and Therapeutic Applications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 23585
Special Issue Editor
Interests: immune response; cytotoxic T cells; B cells; antibodies; autoantibodies; cytokines; antibody dependent cytotoxicity; pathogen associated molecular patterns; pathogen recognition receptors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
T lymphocytes play a key role in developing adaptive immune responses. Their interaction with various subsets of leukocytes is essential for initiating an immune response, maintaining long-term immunity, as well as regulating immune responses. T lymphocyte proliferation and maintenance are supervised by cytokines, chemokines, and growth factors. Failure to control T lymphocyte proliferation and development could lead to autoimmunity and cancer. Therefore, correcting T lymphocyte function is a popular therapeutic approach aiming to restore T lymphocyte efficacy in autoimmunity and cancers. This includes using T cell expression of the TCR gene with defined specificity for cancer treatment. Monoclonal antibodies are also used for treating T cell leukemia. In recent studies, CAR-T cells demonstrated dramatic efficacy in treating hematological malignancies.
This Special Issue will compile the most recent advances in the field, with an emphasis on enhancing the development of cutting-edge strategies aimed to identify the mechanisms regulating activation, proliferation, and development of T lymphocytes. We especially welcome studies identifying novel T lymphocyte markers for disease diagnosis and treatment. Scientists are invited to submit their original research papers, case reports, clinical trials, and review articles with the following potential list of topics:
- Mechanisms of T lymphocytes development, activation, and function in health and pathologies;
- The role of cytokines, chemokines, and growth factors in the regulation of T lymphocyte function in health and pathologies;
- Gene, cell, and gene-cell technologies as the way to regulate T lymphocyte function and deliver therapeutic results;
- Novel markers and approaches for diagnosis and T lymphocyte dysfunction;
- Novel therapeutic approaches targeting T lymphocytes;
- T cell targeting vaccines.
Dr. Svetlana Khaiboullina
Guest Editor
Dr. Svetlana Khaiboullina
Guest Editor
Manuscript Submission Information
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Keywords
- T lymphocyte
- Cancer
- Autoimmunity
- Treatment
- Diagnosis
- CAR-T
- Vaccine
- Cytokines
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