The Many Facets of the Regulation of TCR Signaling 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 2164
Special Issue Editors
Interests: lymphocyte signaling; T-cell receptor signaling; Zap70; Lck; tyrosine kinases; T-cell activation; thymic development; natural products; immunomodulation
Special Issues, Collections and Topics in MDPI journals
Interests: T cell
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
T cells are well-known for their importance in the orchestration of the adaptive immune response. Alterations in the function of T cells are at the basis of many inflammatory disorders including autoimmune diseases, allergy, transplant rejection, reperfusion injury, and cancer as well as in immunodeficiency. T-cell functions critically depend on signaling cascades triggered upon the engagement of the T-cell receptor (TCR). The experimental evidence accumulated over the past decades has demonstrated that the TCR regulates development, activation, differentiation, and homeostasis of T cells. How signaling via a single receptor can dictate different cellular outcomes has intrigued many researchers. It has become clearer that the intensity and the duration of TCR signaling and its integration with signaling cascades downstream of other cell surface receptors operate in concert to dictate the specific cell fate and response.
In this Special Issue, we invite investigators to submit original research or review articles on the many facets in the regulation of TCR signaling.
Topics include but are not limited to the following:
- Dynamic changes of TCR conformation and initiation of TCR signaling
- Orchestration of proximal signaling events
- Propagation of TCR signaling and initiation of transcription
- Signaling molecules: adaptors, kinases, phosphatases, etc.
- Integration of TCR signaling: co-stimulatory molecules
- Inhibition of TCR signaling
- TCR signal strength and TCR signaling dynamics
- Modeling of TCR signaling
- Redox-mediated regulation of TCR signaling
- Engineered TCRs: signaling via CARs
Prof. Dr. Luca Simeoni
Prof. Dr. Ursula Bommhardt
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
