Circulatory System Esterases and Their Physiologic Roles in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 July 2024) | Viewed by 1111
Special Issue Editor
Interests: medicinal chemistry; chemical biology; drug and nucleic acid delivery systems
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The esterases present in the circulatory system hydrolyse ester groups from a large variety of compounds with different molecular weights and lipophilicities that are present in blood as part of body homeostasis or that can appear transiently in circulation due to diet, different disfunctions, or diseases. Since alcohol and acid products are more polar than the parent ester, the action of circulatory esterases generates species with an increased water solubility as compared with the parent ones, speeding up the clearance of potentially harmful lipophilic esters from circulation. A plethora of circulatory system esterases, either present in blood/plasma, attached on the blood vessel walls or contained into various cells present in the bloodstream, ensures the efficient hydrolysis of ester groups in individual compounds or in supramolecular assemblies present in this environment. In this Special Issue, we are encouraging contributions detailing the structure, mechanism of action and physiologic role of different circulatory system esterases, relevance to various diseases, and their activity modulation (inhibition/activation) for therapeutic purposes. The impact of circulatory esterases on the pharmacokinetic of drugs, prodrugs, and drug delivery systems constitutes another focus area of this Special Issue.
Prof. Dr. Marc A. Ilies
Guest Editor
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Keywords
- esterases and lipases
- circulatory system
- blood, plasma, blood vessels, and figurative elements of blood
- physiopathology
- structure and catalysis mechanism
- substrate selectivity
- activity assays
- inhibition and activation
- drugs in clinical use and under development
- prodrugs
- drug delivery systems
- drug pharmacokinetics
- toxicity and detoxification
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