Special Issue "Structural Variability and Flexibility of the Genome"
Deadline for manuscript submissions: closed (30 September 2020).
Interests: chromosome biology; chromosomal rearrangements; small supernumerary marker chromosomes; heteromorphisms; molecular cytogenetics
Special Issues and Collections in MDPI journals
Genomes of eukaryotes are known in more and more detail due to DNA-directed studies at different levels of resolution. Already with the help of cytogenetics, first insights into structural genomic variants, like chromosomal heteromorphims, can be obtained. Underlying copy number variants can be further elucidated by means of molecular cytogenetics, molecular karyotyping, and/or sequencing approaches. Further, epigenetics may play a role for both structural as well as flexible adaptations of genomes under specific evolutionary pressures. In the thus far best studied eukaryotic genome, the human one, copy number variants as well a three-dimensional networking of the genome in ‘topologically associated domains’ (= TADs) are recognized to be important. Even when it comes to the origin of genetic disorders, underlying point mutations are not so much the only reason to be considered anymore.
For this Special Issue, we look forward to receiving original research manuscripts as well as methodological and review articles, with a special focus on structural variability and flexibility of the genome, which can be observable on variant levels (e.g., copy number variants of heterochromatic and euchromatic material, mechanisms of genetic silencing, position effects, 3D structure of the nucleus, epigenetic mechanisms). We are confident that different aspects of eukaryote genome complexity in one volume will provide an important contribution to molecular genetics and genomics.
Dr. Thomas Liehr
Manuscript Submission Information
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- copy number variants
- gene silencing
- position effects
- topologically associated domains (TADs)
- fragile sites
- chromosomal evolution
- repetitive elements
- chromosomal rearrangements