Steroid Metabolism in Human Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (15 January 2021) | Viewed by 25461
Special Issue Editor
Interests: steroid metabolism; steroidogenesis; pregnenolone; cytochrome P450; P450 oxidoreductase; CYP17A1; CYP19A1; androgens; estrogens
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Steroid hormones are necessary for life, from salt balance by mineralocorticoids, sugar balance by glucocorticoids, to the growth, reproductive, and sexual functions of sex steroids.
Steroid hormones are synthesized from cholesterol, starting from conversion, to pregnenolone, which is then converted to many different metabolites in a series of metabolic reactions.
Defects in the steroid metabolism cause a wide range of disorders, including the most common endocrine disorder in women, polycystic ovary syndrome. Therefore, control of steroid hormones production and signalling is an attractive target for the treatment of many metabolic disorders, including hormonal dependent cancers (targeting CYP17A1 and the androgen receptor in prostate cancer, and aromatase in breast cancer).
This Special Issue will focus on the molecular biology and biochemistry of steroid hormones in health and disease, and potential topics of interest may include, but are not limited, to the following:
- Molecular, cellular, and structural biology of steroid hormone production, regulation, and signalling in humans.
- Genetics and pathology of metabolic disorders caused by the changes in steroid metabolism, including the study of human mutations causing disordered steroidogenesis.
- Novel genes and mechanisms regulating steroid biosynthesis.
- Targeting of steroid hormone production, regulation, and signalling in metabolic disorders, including hormone-dependent cancers, by drugs and protein therapeutics.
Through this Special Issue, we aim to provide the latest work on the topic of steroid metabolism in human health and disease by experts in the field to a broad range of readership.
Dr. Amit V. Pandey
Guest Editor
Manuscript Submission Information
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Keywords
- Steroid biosynthesis
- Steroidogenesis
- Androgen
- Estrogen
- Hormone-dependent cancers
- Metabolic disorders
- Steroid metabolizing enzymes
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