Wnt/β-Catenin Signaling in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (25 July 2023) | Viewed by 9674
Special Issue Editor
Interests: clinical biochemistry; inflammation; oxidative stress; neurodegeneration; natural compounds
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Wnts are a family of proteins that modulate cellular processes such as proliferation, differentiation, and migration. This family includes 19 members of secreted lipid-modified signaling mediators. Currently, three Wnt signaling pathways have been identified; the canonical Wnt/β-catenin pathway is the best-studied and appears to be involved in the pathophysiology of various CNS disorders. In this pathway, Wnt ligands bind to the cysteine-rich domain frizzled (FZ) receptors which in turn activate several intracellular signaling cascades. At the intracellular level, Wnt/FZ requires the intracellular β-catenin protein, whose levels remain low by the action of a so-called destruction complex. Wnt signaling activation leads to the dissociation of the β-catenin destruction complex; as a consequence, β-catenin accumulates in the cytoplasm and translocates to the nucleus, finally inducing the expression of Wnt target genes. The deregulation of Wnt/β-catenin signaling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and pre-clinical and clinical trials of the Wnt/β-catenin signaling pathway in tumors and diseases is lacking.
This Special Issue will focus on the role of Wnt/β-Catenin signaling as a promising therapeutic target for health and disease. The Special Issue will feature original in vivo and in vitro reviews and studies providing evidence of the welfare effects of novel compounds with no side effects.
Dr. Rosalba Siracusa
Guest Editor
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Keywords
- acute disease
- chronic disease
- inflammation
- natural compounds
- small molecules
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