Sexual Dimorphism in Neurological Diseases: From Molecular Basis to Therapy
Deadline for manuscript submissions: closed (15 February 2023) | Viewed by 5380
2. Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, 3000-548 Coimbra, Portugal
Interests: neurodevelopmental disorders; gestational nutrition; sex dimorphism; excitation/inhibition balance; animal behavior
Neurological disorders, including multiple sclerosis, migraine, depression, autism spectrum disorder, etc., show strong sex differences in their incidence and disease manifestation. In recent years, the importance of biological sex as a vital factor determining underlying mechanisms of disease and cognitive vulnerability has been substantiated with a direct impact on both the diagnosis and therapeutic response. Indeed, research conducted in this field offers the promise of developing more personalized treatments for both males and females. Accumulating evidence suggests a complex mechanistic scenario with a genetic predisposition and endocrine and environmental factors as interacting components governing diseases’ onset, progression, and severity.
Therefore, sex differences in brain organization and mechanisms, and consequently in behavior, may explain differential disease vulnerability between males and females.
With this in mind, we would like to invite the submission of reviews and original articles addressing the latest achievements in our understanding the mechanisms underlying sex differences in neurological conditions (both in neurodegenerative disorders and in neurodevelopmental disorders), as well as possible sex-targeted therapies for brain diseases.
Dr. Joana Gonçalves
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- sex dimorphism
- neurodegenerative disorders
- neurodevelopmental disorders
- neurotransmitter metabolism
- gut-brain axis
- sex-targeted therapies