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MicroRNA/Long Non Coding RNA Networking in Cancer Therapeutics and Diagnostics
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MicroRNA/Long Non Coding RNA Networking in Cancer Therapeutics and Diagnostics

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (5 May 2021) | Viewed by 8094

Special Issue Editors

Prof. Dr. Michele Caraglia

E-Mail Website1 Website2
Guest Editor
Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy
Interests: cancer; miRNAs; nanotechnology; drug delivery; nanosensors; long noncoding RNA; signal transduction; isoprenylation and cancer; aminobisphosphonates; glioblastoma; prostate cancer; hepatocellular cancer; head and neck cancer; Ras; interferons
Special Issues, Collections and Topics in MDPI journals
Dr. Marianna Scrima

E-Mail Website
Guest Editor
Biogem scarl, Institute of Genetic Research, Laboratory of Molecular and Precision Medicine, 83031 Ariano Irpino (AV), Italy
Interests: cancer; miRNAs; long noncoding RNA; laryngeal cancer; lung cancer; liquid biopsy; circulating tumor cell; diagnostic biomarkers; signal transduction; cell cycle; PI3K/AKT Pathway; apoptosis; autophagy
Dr. Alessia Maria Cossu

E-Mail Website
Guest Editor
Biogem scarl, Institute of Genetic Research, Laboratory of Molecular and Precision Medicine, 83031 Ariano Irpino (AV), Italy
Interests: cancer; miRNA; long non-coding RNA; laryngeal cancer; glioblastoma; liquid biopsy; diagnostic biomarkers; anti-inflammatory drugs; cell cycle; apoptosis; autophagy; cancer-related biochemical pathways; drug delivery; small molecule inhibitors; nanotechnology/nanoparticles

Special Issue Information

This Special issue of the International Journal of Molecular Sciences will focus on recent advances in “MicroRNA/long Noncoding RNA Networking in Cancer Therapeutics and Diagnostics”, including new findings concerning miRNAs and long noncoding RNAs as tumor suppressors or oncogenes by regulating one or several cancer hallmarks, including evading cell death, metastasis, drug resistance, and immunological escape; as well as emerging data on miRNA–lncRNA interactions that affect cell death regulation and mechanisms of resistance to therapy. Abnormally expressed miRNAs are strongly associated with cancer development, resistance to chemo-/radiotherapy and anti-cancer immunotherapy, and metastatic potential through targeting a large variety of genes. Current research progress on noncoding (ncRNAs) for clinical and/or potential translational applications, including the identification of novel therapeutic approaches for ncRNA targeting, delivery strategies, will also be appreciated. Circulating ncRNAs are also a useful chance to diagnose a cancer determining its biological aggressiveness features in the field of the so-called “liquid biopsy". New methodological approaches based on the development of nanotechnology-based tools are a new frontier in the determination of circulating ncRNAs in body fluids. Contributions on the definition of ncRNAs as diagnostic and prognostic circulating biomarkers in human cancers and the relative development of cheap and easy-to-use nanosensors will also be well accepted.

The aim of this Special Issue is to present the latest research on the identification of new miRNAs/long noncoding RNA networking as a new opportunity to access better clinical management of malignancies.

Prof. Dr. Michele Caraglia
Dr. Marianna Scrima
Dr. Alessia Maria Cossu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • miRNAs
  • circulating miRNA
  • noncoding RNA
  • cancer
  • epigenetics
  • disease biomarkers
  • nanosensors
  • diagnostics
  • prognosticators
  • predictive biomarkers of response
  • miRNA sponge
  • liquid biopsy
  • therapeutics
  • next-generation sequencing (NGS)

Published Papers (2 papers)

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Review

14 pages, 1044 KiB  
Review
Role of miRNA-19a in Cancer Diagnosis and Poor Prognosis
by Alessio Ardizzone, Giovanna Calabrese, Michela Campolo, Alessia Filippone, Dario Giuffrida, Francesca Esposito, Cristina Colarossi, Salvatore Cuzzocrea, Emanuela Esposito and Irene Paterniti
Int. J. Mol. Sci. 2021, 22(9), 4697; https://doi.org/10.3390/ijms22094697 - 29 Apr 2021
Cited by 25 | Viewed by 3082
Abstract
Cancer is a multifactorial disease that affects millions of people every year and is one of the most common causes of death in the world. The high mortality rate is very often linked to late diagnosis; in fact, nowadays there are a lack [...] Read more.
Cancer is a multifactorial disease that affects millions of people every year and is one of the most common causes of death in the world. The high mortality rate is very often linked to late diagnosis; in fact, nowadays there are a lack of efficient and specific markers for the early diagnosis and prognosis of cancer. In recent years, the discovery of new diagnostic markers, including microRNAs (miRNAs), has been an important turning point for cancer research. miRNAs are small, endogenous, non-coding RNAs that regulate gene expression. Compelling evidence has showed that many miRNAs are aberrantly expressed in human carcinomas and can act with either tumor-promoting or tumor-suppressing functions. miR-19a is one of the most investigated miRNAs, whose dysregulated expression is involved in different types of tumors and has been potentially associated with the prognosis of cancer patients. The aim of this review is to investigate the role of miR-19a in cancer, highlighting its involvement in cell proliferation, cell growth, cell death, tissue invasion and migration, as well as in angiogenesis. On these bases, miR-19a could prove to be truly useful as a potential diagnostic, prognostic, and therapeutic marker. Full article
(This article belongs to the Special Issue MicroRNA/Long Non Coding RNA Networking in Cancer Therapeutics and Diagnostics)
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29 pages, 2154 KiB  
Review
LncRNAs and Immunity: Coding the Immune System with Noncoding Oligonucleotides
by Marco Bocchetti, Marianna Scrima, Federica Melisi, Amalia Luce, Rossella Sperlongano, Michele Caraglia, Silvia Zappavigna and Alessia Maria Cossu
Int. J. Mol. Sci. 2021, 22(4), 1741; https://doi.org/10.3390/ijms22041741 - 09 Feb 2021
Cited by 33 | Viewed by 4371
Abstract
Long noncoding RNAs (lncRNAs) represent key regulators of gene transcription during the inflammatory response. Recent findings showed lncRNAs to be dysregulated in human diseases, such as inflammatory bowel disease, diabetes, allergies, asthma, and cancer. These noncoding RNAs are crucial for immune mechanism, as [...] Read more.
Long noncoding RNAs (lncRNAs) represent key regulators of gene transcription during the inflammatory response. Recent findings showed lncRNAs to be dysregulated in human diseases, such as inflammatory bowel disease, diabetes, allergies, asthma, and cancer. These noncoding RNAs are crucial for immune mechanism, as they are involved in differentiation, cell migration and in the production of inflammatory mediators through regulating protein–protein interactions or their ability to assemble with RNA and DNA. The last interaction can occur in cis or trans and is responsible for all the possible lncRNAs biological effects. Our proposal is to provide an overview on lncRNAs roles and functions related to immunity and immune mediated diseases, since these elucidations could be beneficial to untangle the complex bond between them. Full article
(This article belongs to the Special Issue MicroRNA/Long Non Coding RNA Networking in Cancer Therapeutics and Diagnostics)
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