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Biomaterials and Antimicrobial Materials for Orthopaedic Application 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 1548

Special Issue Editor


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Special Issue Information

Dear Colleagues,

Bone is a complex tissue that continuously undergoes dynamic biological remodelling to maintain homeostasis. However, healing in large and critical defect areas is often impaired, leading to inferior bone regeneration and extended hospitalization periods. Along with this, the increasing number of bone fractures and orthopaedic-related injuries due to the exponential growth of the elderly population has prompted researchers to explore biomaterials to address these issues. To promote bone regeneration, many therapeutic strategies have been suggested, including scaffolds, stem cells, and growth factors. Moreover, antimicrobial effects should be considered due to their ability to protect against infection. Hence, the selection of appropriate biomaterials has become one of the key success paths for orthopaedic applications.

This Special Issue focuses on studies and applications of biomaterials and/or antimicrobial materials that are essential for orthopaedic applications. The main aim of this Special Issue is to publish original research articles that showcase the advanced development of biomaterials for orthopaedic applications, antimicrobial scaffolding for bone tissue engineering, or a comprehensive analysis of antimicrobial materials. Review articles that discuss the current trends in the field of antimicrobial biomaterials in orthopaedic applications will also be considered in this Special Issue.

Research areas may include (but are not limited to) the following:

  • Biomaterials for orthopaedic applications;
  • The role of antibacterial biomaterials in regenerative medicine;
  • Bone tissue engineering scaffolds with antibacterial activity;
  • Mechanisms of action of antimicrobial nanomaterials;
  • Future perspectives for antimicrobial nanomaterials.

I look forward to receiving your contributions.

Prof. Dr. Irena Maliszewska
Guest Editor

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Keywords

  • biomaterials
  • antimicrobial materials
  • orthopaedic application
  • regenerative medicine
  • biocompatible polymers
  • scaffold tissue engineering
  • bone regeneration
  • spine
  • hydrogel
  • cryogel
  • stem cell

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Published Papers (1 paper)

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Research

15 pages, 9156 KiB  
Article
Antisolvent 3D Printing of Gene-Activated Scaffolds for Bone Regeneration
by Andrey Vyacheslavovich Vasilyev, Irina Alekseevna Nedorubova, Viktoria Olegovna Chernomyrdina, Anastasiia Yurevna Meglei, Viktoriia Pavlovna Basina, Anton Vladimirovich Mironov, Valeriya Sergeevna Kuznetsova, Victoria Alexandrovna Sinelnikova, Olga Anatolievna Mironova, Ekaterina Maksimovna Trifanova, Igor Ivanovich Babichenko, Vladimir Karpovich Popov, Anatoly Alekseevich Kulakov, Dmitry Vadimovich Goldshtein and Tatiana Borisovna Bukharova
Int. J. Mol. Sci. 2024, 25(24), 13300; https://doi.org/10.3390/ijms252413300 - 11 Dec 2024
Viewed by 1022
Abstract
The use of 3D-printed gene-activated bone grafts represents a highly promising approach in the fields of dentistry and orthopedics. Bioresorbable poly-lactic-co-glycolic acid (PLGA) scaffolds, infused with adenoviral constructs that carry osteoinductive factor genes, may provide an effective alternative to existing bone grafts for [...] Read more.
The use of 3D-printed gene-activated bone grafts represents a highly promising approach in the fields of dentistry and orthopedics. Bioresorbable poly-lactic-co-glycolic acid (PLGA) scaffolds, infused with adenoviral constructs that carry osteoinductive factor genes, may provide an effective alternative to existing bone grafts for the reconstruction of extensive bone defects. This study aims to develop and investigate the properties of 3D scaffolds composed of PLGA and adenoviral constructs carrying the BMP2 gene (Ad-BMP2), both in vitro and in vivo. The elastic modulus of the disk-shaped PLGA scaffolds created using a specialized 3D printer was determined by compressive testing in both axial and radial directions. In vitro cytocompatibility was assessed using adipose-derived stem cells (ADSCs). The ability of Ad-BMP2 to transduce cells was evaluated. The osteoinductive and biocompatible properties of the scaffolds were also assessed in vivo. The Young’s modulus of the 3D-printed PLGA scaffolds exhibited comparable values in both axial and radial compression directions, measuring 3.4 ± 0.7 MPa for axial and 3.17 ± 1.4 MPa for radial compression. The scaffolds promoted cell adhesion and had no cytotoxic effect on ADSCs. Ad-BMP2 successfully transduced the cells and induced osteogenic differentiation in vitro. In vivo studies demonstrated that the 3D-printed PLGA scaffolds had osteoinductive properties, promoting bone formation within the scaffold filaments as well as at the center of a critical calvarial bone defect. Full article
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