Molecular Insights into Type 2 Diabetes and Its Complications

Dear Colleagues,

Type 2 diabetes is on the rise and has become a widespread epidemic in recent years. It is one of the leading causes of cardiovascular disease, blindness, end-stage renal disease, and non­traumatic lower-limb amputations, leading to growing social and clinical burdens globally. As a result, an enriched understanding of the pathogenesis of type 2 diabetes along with attempts to sort out and carry out effective approaches to prevent or treat type 2 diabetes or its macro- and micro-vascular complications are of paramount importance.

A large body of evidence has well documented that metabolic defects, such as islet β-cell dysfunction, reduced incretin response, and impaired autonomic function, are commonly observed in patients with type 2 diabetes. They may drive the development of type 2 diabetes and contribute to the increased risk of diabetes-related complications. The aim of this Special Issue is to promote the latest research in physiology that focuses on the metabolic defects underlying the onset of type 2 diabetes or its complications, with a particular focus on the association between type 2 diabetes mellitus and cardiovascular disease, with direct or indirect connections to the clinical applications and/or practices. We also plan to advance our knowledge about the effectiveness of lifestyle modifications, such as increased physical activity or reduced sedentary time, for managing type 2 diabetes. We will focus on the mechanisms that mediate alterations of metabolic defects induced by lifestyle modifications, wishing to provide interactions and/or communications between basic and clinical researchers. Manuscripts in the form of original articles, reviews, and commentaries are welcome for submission to this Special Issue.

Prof. Dr. Maria Perticone
Guest Editor

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