Molecular Insights into Type 2 Diabetes and Its Complications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 3403
Special Issue Editor
Interests: obesity; type-2 diabetes; metabolic syndrome; endothelial dysfunction; hypertension; target organ damage
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Type 2 diabetes is on the rise and has become a widespread epidemic in recent years. It is one of the leading causes of cardiovascular disease, blindness, end-stage renal disease, and nontraumatic lower-limb amputations, leading to growing social and clinical burdens globally. As a result, an enriched understanding of the pathogenesis of type 2 diabetes along with attempts to sort out and carry out effective approaches to prevent or treat type 2 diabetes or its macro- and micro-vascular complications are of paramount importance.
A large body of evidence has well documented that metabolic defects, such as islet β-cell dysfunction, reduced incretin response, and impaired autonomic function, are commonly observed in patients with type 2 diabetes. They may drive the development of type 2 diabetes and contribute to the increased risk of diabetes-related complications. The aim of this Special Issue is to promote the latest research in physiology that focuses on the metabolic defects underlying the onset of type 2 diabetes or its complications, with a particular focus on the association between type 2 diabetes mellitus and cardiovascular disease, with direct or indirect connections to the clinical applications and/or practices. We also plan to advance our knowledge about the effectiveness of lifestyle modifications, such as increased physical activity or reduced sedentary time, for managing type 2 diabetes. We will focus on the mechanisms that mediate alterations of metabolic defects induced by lifestyle modifications, wishing to provide interactions and/or communications between basic and clinical researchers. Manuscripts in the form of original articles, reviews, and commentaries are welcome for submission to this Special Issue.
Prof. Dr. Maria Perticone
Guest Editor
Manuscript Submission Information
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Keywords
- diabetes
- metabolic defects
- β-cell function
- dietary intervention
- physical exercise
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