Application of Genetic Engineering in Treatments for Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 1816
Special Issue Editor
2. Center for Chronic Immunodeficiency (CCI), Medical Center—University of Freiburg, 79106 Freiburg, Germany
3. Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
Interests: gene therapy; genome editing; epigenome editing; designer nucleases; CRISPR-Cas
Special Issue Information
Dear Colleagues,
Genome and epigenome editing technologies have advanced significantly in recent years, driven by their vast therapeutic potential. Genome editing involves precise alterations to an organism's DNA, enabling the correction of genetic mutations, the insertion of new genetic material, or the deletion of faulty genes. In contrast, epigenome editing focuses on modifying chemical markers on DNA or associated proteins, regulating gene expression without altering the underlying genetic sequence. Together, these approaches offer a powerful toolbox for manipulating biological systems at their most fundamental level. They hold promise for a wide range of diseases, including cancer, cardiovascular disorders, neurodegenerative conditions, and even viral infections. The ability to tailor therapies at the genetic or epigenetic level heralds a new era in medicine, where treatments can be customized to the specific needs of individual patients.
This Special Issue of IJMS welcomes original research articles, reviews, and case studies that explore the full spectrum of genome and epigenome editing approaches and their therapeutic potential. We particularly encourage submissions that delve into the molecular mechanisms underlying these technologies, shedding light on these innovative treatments' precision, efficacy, and safety. Topics of interest include, but are not limited to:
- Novel genome and epigenome editing technologies and their applications in disease treatment;
- Molecular insights into the efficacy and safety of editing approaches;
- Therapeutic innovations using genome and epigenome editing for genetic disorders, cancer, and complex diseases;
- Combinatorial approaches with gene therapies and other biomedical strategies;
- Advances in delivery systems and techniques for in vivo and ex vivo editing;
- Ethical considerations and long-term impacts of therapeutic genome and epigenome editing.
We invite researchers and clinicians to contribute to this exciting and rapidly advancing field, providing critical insights to shape the next generation of human therapeutics.
Dr. Claudio Mussolino
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- genome editing
- epigenome editing
- CRISPR-Cas systems
- gene therapy
- precision medicine
- molecular mechanisms
- innovative therapies
- gene expression regulation
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
