Special Issue "Proteomics and Its Applications in Cancers"
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 3590
2. Institute of Biomedical Chemistry, Pogodinskaya, 10, 119121 Moscow, Russia
Interests: proteomics; cancer; biomarkers; extracellular vesicles; glioblastoma; haptoglobin; plasma; proteoforms; 2DE; databases
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It is known that the vast majority of pathological changes in the functioning of cells, tissues, and organs are accompanied by a deviation from the physiological protein profile of a normal healthy organism. In modern conditions, the analysis and prediction of such changes come to the fore in the creation of preclinical screening protocols (i.e., the determination of hidden and latent protein "precursors" of the disease, as well as the assessment of the effectiveness of the applied therapy methods). The search, determination, separation, quantitative, and qualitative identification of protein molecules that play a role in providing sensitivity or directly in the formation of a disease are the main tasks of proteomics. The most popular is the comparative analysis of proteomes in the field of cancer research. Here, much should be expected from proteomics and systems approaches, which could allow the development of detection of cancerous and precancerous conditions based on the analysis of not one, but a group of markers. The determination of the proteomic profile by mass spectrometry or immunodetection allows the identification of individual protein forms (proteoforms) and the observation of changes in their number and composition in health and disease, as well as under the influence of various factors. The detection of changes in proteoform profiles associated with pathology enables the selection of the most characteristic markers of the diseases and their use for inclusion in the developed barcodes, which represent powerful tools for monitoring the course of cancer and the efficacy and safety of therapeutic agents. However, the analysis of large data sets obtained in various conditions (for example, normal, inflammation, and cancer) and in different tissues and organs is now coming to the fore. Thus, there is a need for standardized processes for storing and retrieving data obtained using different methods and by different researchers; that is, in addition to the development of technologies and the acquisition of new data, there is a need for their organization, formatting, and analysis, which is critical for answering clinical questions in cancer research. Additionally, here, bioinformatics plays a decisive role. In this Special Issue, we would like to gather contributions reporting very recent advances in the proteomics study of cancer. We invite you to participate in this Special Issue.
Prof. Dr. Stanislav Naryzhny
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- drug target
- post-translational modifications
- mass spectrometry