Special Issue "Molecular Biology of the Pituitary"
Deadline for manuscript submissions: closed (30 November 2020).
Interests: pituitary, acromegaly, Cushing’s syndrome, hyerprolactinemia, TSH-secreting pituitary adenoma, syndrome of reduced sensitivity to thyroid hormones, thyroid, adrenal gland
Interests: pituitary; acromegaly; Cushing’s syndrome; hyperprolactinemia; TSH-secreting pituitary adenoma; syndrome of reduced sensitivity to thyroid hormones; thyroid; adrenal gland
This Special Issue aims to present recent research on the molecular biology of pituitary diseases. Pituitary adenoma is a common disease, present in about 10% of the general population, which generally presents as benign tumors. However, rarely, tumors can become malignant and metastasize. Pituitary adenomas are also associated with specific syndromes (e.g., acromegaly, Cushing’s syndrome, prolactinoma, inappropriate TSH secretion syndrome) due to inappropriate hormonal secretion. The continuous development of molecular biology techniques has improved the understanding of both the pathogenesis and the biology of these tumors and this knowledge can be applied for the development of diagnostic approaches and therapeutic options. Interestingly, molecular biology techniques have led to the discovery of the pathophysiological mechanisms at the basis of non-neoplastic pituitary diseases, such as thyroid hormone resistance syndrome or non-neoplastic TSH inappropriate secretion. Regarding syndromes of reduced sensitivity to thyroid hormones, an important topic is the discovery of polymorphisms in genes which code for type 2 deiodinase. Finally, genetic analyses can identify mutations of genes coding for transcription factors involved in pituitary development, which can be involved in the pathogenesis of combined pituitary hormone deficiency.
Prof. Dr. Salvatore M. Corsello
Dr. Rosa Maria Paragliola
Manuscript Submission Information
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- somatostatin receptor ligands
- Cushing’s syndrome
- TSH-secreting adenomas
- syndromes of reduced sensitivity to thyroid hormones
- pituitary adenomas
- pituitary carcinomas