Special Issue "Pharmacologic Targeting of the Tumor Microenvironment"
Deadline for manuscript submissions: 31 January 2021.
Interests: tumor microenvironment; cell–cell signaling; cell metabolism; hypoxia; oxidative stress; drug repurposing; ovarian cancer; breast cancer
Progress in our understanding of the complex composition of the tumor microenvironment has revealed the critical influence of stromal cells (e.g., fibroblasts, adipocytes, endothelial cells) in the ability of tumors to rapidly grow and metastasize to secondary tissues. Recent research has identified novel signaling mechanisms by which tumor–stroma interactions, in part due to signals emanating from stromal cells, facilitate key mechanisms involved in tumor cell proliferation, clonogenicity, migration, adhesion, and invasion. These interactions potentially provide a new set of therapeutic liabilities to target pharmacologically, to refine clinical strategies, and ultimately to improve patient outcomes. Here, in this Special Issue on “Pharmacologic Targeting of the Tumor Microenvironment”, we shall discuss the ability of repurposed and novel compounds to modulate tumor–stroma interactions with a focus on the efficacy of pharmacologic agents to impede bidirectional signaling mechanisms required for tumor development and metastatic progression.
This issue of the International Journal of Molecular Sciences is open to both original research articles and review articles focusing on advances in preclinical evaluation of pharmacologic approaches to modulate the tumor microenvironment in order to inhibit cancer progression.
Dr. Peter C. Hart
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- tumor microenvironment
- endothelial cell