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Special Issue "Pharmacologic Targeting of the Tumor Microenvironment"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 January 2021.

Special Issue Editor

Dr. Peter C. Hart
Website
Guest Editor
Roosevelt University, College of Pharmacy, 1400 N Roosevelt Blvd | Schaumburg, IL, USA
Interests: tumor microenvironment; cell–cell signaling; cell metabolism; hypoxia; oxidative stress; drug repurposing; ovarian cancer; breast cancer

Special Issue Information

Dear Colleagues,

Progress in our understanding of the complex composition of the tumor microenvironment has revealed the critical influence of stromal cells (e.g., fibroblasts, adipocytes, endothelial cells) in the ability of tumors to rapidly grow and metastasize to secondary tissues. Recent research has identified novel signaling mechanisms by which tumor–stroma interactions, in part due to signals emanating from stromal cells, facilitate key mechanisms involved in tumor cell proliferation, clonogenicity, migration, adhesion, and invasion. These interactions potentially provide a new set of therapeutic liabilities to target pharmacologically, to refine clinical strategies, and ultimately to improve patient outcomes. Here, in this Special Issue on “Pharmacologic Targeting of the Tumor Microenvironment”, we shall discuss the ability of repurposed and novel compounds to modulate tumor–stroma interactions with a focus on the efficacy of pharmacologic agents to impede bidirectional signaling mechanisms required for tumor development and metastatic progression.

This issue of the International Journal of Molecular Sciences is open to both original research articles and review articles focusing on advances in preclinical evaluation of pharmacologic approaches to modulate the tumor microenvironment in order to inhibit cancer progression.

Dr. Peter C. Hart
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tumor microenvironment
  • stroma
  • fibroblast
  • adipocyte
  • leukocyte
  • endothelial cell
  • metastasis

Published Papers (2 papers)

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Research

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Open AccessArticle
Impact of the Stroma on the Biological Characteristics of the Parenchyma in Oral Squamous Cell Carcinoma
Int. J. Mol. Sci. 2020, 21(20), 7714; https://doi.org/10.3390/ijms21207714 - 18 Oct 2020
Abstract
Solid tumors consist of the tumor parenchyma and stroma. The standard concept of oncology is that the tumor parenchyma regulates the tumor stroma and promotes tumor progression, and that the tumor parenchyma represents the tumor itself and defines the biological characteristics of the [...] Read more.
Solid tumors consist of the tumor parenchyma and stroma. The standard concept of oncology is that the tumor parenchyma regulates the tumor stroma and promotes tumor progression, and that the tumor parenchyma represents the tumor itself and defines the biological characteristics of the tumor tissue. Thus, the tumor stroma plays a pivotal role in assisting tumor parenchymal growth and invasiveness and is regarded as a supporter of the tumor parenchyma. The tumor parenchyma and stroma interact with each other. However, the influence of the stroma on the parenchyma is not clear. Therefore, in this study, we investigated the effect of the stroma on the parenchyma in oral squamous cell carcinoma (OSCC). We isolated tumor stroma from two types of OSCCs with different invasiveness (endophytic type OSCC (ED-st) and exophytic type OSCC (EX-st)) and examined the effect of the stroma on the parenchyma in terms of proliferation, invasion, and morphology by co-culturing and co-transplanting the OSCC cell line (HSC-2) with the two types of stroma. Both types of stroma were partially positive for alpha-smooth muscle actin. The tumor stroma increased the proliferation and invasion of tumor cells and altered the morphology of tumor cells in vitro and in vivo. ED-st exerted a greater effect on the tumor parenchyma in proliferation and invasion than EX-st. Morphological analysis showed that ED-st changed the morphology of HSC-2 cells to the invasive type of OSCC, and EX-st altered the morphology of HSC-2 cells to verrucous OSCC. This study suggests that the tumor stroma influences the biological characteristics of the parenchyma and that the origin of the stroma is strongly associated with the biological characteristics of the tumor. Full article
(This article belongs to the Special Issue Pharmacologic Targeting of the Tumor Microenvironment)
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Open AccessReview
Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19
Int. J. Mol. Sci. 2020, 21(21), 7937; https://doi.org/10.3390/ijms21217937 - 26 Oct 2020
Abstract
Interleukin-6 (IL-6) is a cytokine with multifaceted effects playing a remarkable role in the initiation of the immune response. The increased level of this cytokine in the elderly seems to be associated with the chronic inflammatory setting of the microenvironment in aged individuals. [...] Read more.
Interleukin-6 (IL-6) is a cytokine with multifaceted effects playing a remarkable role in the initiation of the immune response. The increased level of this cytokine in the elderly seems to be associated with the chronic inflammatory setting of the microenvironment in aged individuals. IL-6 also represents one of the main signals in communication between cancer cells and their non-malignant neighbours within the tumour niche. IL-6 also participates in the development of a premetastatic niche and in the adjustment of the metabolism in terminal-stage patients suffering from a malignant disease. IL-6 is a fundamental factor of the cytokine storm in patients with severe COVID-19, where it is responsible for the fatal outcome of the disease. A better understanding of the role of IL-6 under physiological as well as pathological conditions and the preparation of new strategies for the therapeutic control of the IL-6 axis may help to manage the problems associated with the elderly, cancer, and serious viral infections. Full article
(This article belongs to the Special Issue Pharmacologic Targeting of the Tumor Microenvironment)
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