Molecular Pathology and Therapy on Cystic Fibrosis and CFTR-Related Diseases

Dear Colleagues, 

Cystic fibrosis (CF) is caused by the congenital loss of function of CF transmembrane conductance regulator (CFTR), a cAMP-regulated Cl^- channel expressing at the plasma membrane of epithelial cells. Dysregulated CFTR function caused by genetic and/or environmental stresses could participate in the pathogenesis of diseases including chronic obstructive pulmonary disease (COPD), asthma, and bronchiectasis. Thus, understanding the molecular mechanism of dysregulated CFTR function can help us to develop novel therapeutic approaches for the CFTR-related diseases associated with CFTR mutations and polymorphisms. Moreover, in addition to traditional small-molecule CFTR modulators, new chemical modalities including oligonucleotides, molecular glues, and gene therapy may provide novel therapeutic approaches for CFTR-related diseases. 

This Special Issue on “Molecular Pathology and Therapy on Cystic Fibrosis and CFTR-Related Diseases” will gather reviews and original articles focused on the molecular pathology of CFTR-related diseases and novel therapeutic approaches at basic, translational, and clinical levels to provide expert insights and perspectives on advances in the field.

Prof. Dr. Tsukasa Okiyoneda
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.