Proton-Pump Inhibitors (PPIs)

Dear Colleagues,

Proton–pump inhibitors (PPIs) are used by up to 10% of the population in Western countries. They vitually take away a biological function, the production of acidic gastric juice. Normally, gastric acidity is maintained by the Helicobacter pylori regulated release of gastrin from the G cell. Drug-induced hypoacidity induces hypergastrinemia. Gastrin stimulates the ECL cell to release histamine and to proliferate. Based on old animal studies, there has been a fear that long-term profound acid inhibition would also induce gastric neoplasia in humans. In recent years, there have been reports substantiating this view. The present issue of the International Journal of Molecular Sciences will explore all facets related to use of PPIs and particularly the safety aspects. 

Prof. Dr. Helge L. Waldum
Guest Editor

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