Special Issue "Proton-Pump Inhibitors (PPIs)"
Deadline for manuscript submissions: 25 September 2019
Proton–pump inhibitors (PPIs) are used by up to 10% of the population in Western countries. They vitually take away a biological function, the production of acidic gastric juice. Normally, gastric acidity is maintained by the Helicobacter pylori regulated release of gastrin from the G cell. Drug-induced hypoacidity induces hypergastrinemia. Gastrin stimulates the ECL cell to release histamine and to proliferate. Based on old animal studies, there has been a fear that long-term profound acid inhibition would also induce gastric neoplasia in humans. In recent years, there have been reports substantiating this view. The present issue of the International Journal of Molecular Sciences will explore all facets related to use of PPIs and particularly the safety aspects.
Prof. Dr. Helge L. Waldum
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- gastric acidity
- biological function of gastric juice
- regulation of gastric acid secretion
- acid related disease
- inhibitors of gastric acid secretion
- PPIs and potassium-competitive acid blockers (P-CABs)
- Helicobacter pylori
- ECL cell
- gastric neuroendocrine tumors (NETs) and cancer
- infections secondary to gastric hypoacidity
- treatment of acid related diseases