Oxygen Variations

Dear Colleagues,

For over 100 years, our focus in studying human physiology has been aimed at steady states. Understandably, this was a clear need, since we wanted to reassure ourselves of the validity of measurements and the stability of the assessments that were performed. Moreover, the measurement systems that we used were slow and unstable, and a long calibration or “warm up” of instruments was needed to stabilize the measurements. This trend has changed in recent years. Our systems are now fast and stable enough to ensure accurate measurements even in very short timeframes. This opens up a wide range of new approaches and scientific paradigms. This means that research at present and in the future can focus on changes, or unsteady states.

We want to aim towards the future with this new Special Issue of the International Journal of Molecular Sciences within the Biochemistry & Molecular Biology section and particularly on Oxygen Changes or Deltas. We strongly believe that even fast or minute oxygen changes can be very powerful triggers in different adaptive cellular mechanisms. Every change in PO2, whether positive of negative, is of interest in this topic. We want to overcome the idea of hyperoxia or hypoxia, but rather focus on deltas and variations within all ranges, including hypoxic, hyperoxic, hypobaric, hyperbaric, etc. Every contribution on these topics will be welcomed.

Prof. Dr. Costantino Balestra
Prof. Dr. Fabio Virgili
Prof. Dr. Simona Mrakic-Sposta
Guest Editors

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