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Special Issue "Oxidative Stress in Hypertension: Mechanisms and Potential Pharmacological Targets"
Deadline for manuscript submissions: 30 June 2020.
Hypertension represents a major risk factor for stroke, myocardial infarction, and heart failure, which cause one-third of deaths worldwide. Hypertension is a multifactorial disorder involving perturbations of the vasculature, kidney, and immune and central nervous systems. Despite treatment with multiple drugs, 37% of hypertensive patients remain hypertensive, likely due to mechanisms contributing to blood pressure elevation that are not affected by current treatments. Unraveling the underlying causes of vascular dysfunction is critical to improving disease burden. Metabolic disorders and oxidative stress contribute to the pathogenesis of vascular dysfunction and hypertension which are associated with mitochondrial dysfunction and altered cell redox signaling. Targeting specific sources of oxidative stress such as NADPH oxidases or mitochondrial metabolic functions can improve vascular function, reduce hypertension, and reduce morbidity and mortality associated with these pathological conditions.
In this Special Issue, we will discuss the novel mechanisms of oxidative stress, its role in metabolic dysregulation and inflammation, and describe the therapeutic potential of targeting specific oxidative stress and metabolic pathways to improve vascular function and reduce hypertension.
Prof. Anna Dikalova
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Essential hypertension
- Pulmonary hypertension
- Endothelial dysfunction
- Vascular hypertrophy
- Oxidative stress
- Metabolic conditions
- Superoxide radical
- Superoxide dismutase
- NADPH oxidase