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Advances in Molecular Physics and Optical Materials

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 2033

Special Issue Editor

Special Issue Information

Dear Colleagues,

Molecular materials constitute the basis and are the cornerstone for the development of materials with a plethora of applications (e.g., drug design, optoelectronics, and energy storage). Molecular materials enrich our daily lives in countless ways, having properties that depend on their exact structure, the degree of order in the way the molecules are aligned, and their crystalline nature. Small changes in molecular structure can totally alter the properties of the material in bulk and tune its overall characteristics. Therefore, it is of paramount importance to place emphasis on the study of the physics and chemistry of molecular functional materials that demonstrate a wide range of physical phenomena. The field of molecular materials research includes the: (i) preparation, (ii) characterization, and (iii) modeling of potentially useful materials with enhanced physical, chemical, and biomedical properties. The aim of this Special Issue is to highlight recent advances in the physics underlying various phenomena governed by the interaction of light with matter on a molecular basis and how tailoring of the interaction could lead to the development of state-of-the-art molecular materials.

Suggested topics include, but are not limited to, the following:

  • Development of hybrid organic–inorganic materials (e.g., MOFS and COFS) as non-linear optical materials.
  • Physics and chemistry of molecular materials.
  • Novel approaches for the simulation of the interaction of light with molecular materials.
  • Molecular inorganic conductors and superconductors.
  • Theory and simulation of non-linear optics.
  • Quantum chemistry and non-linear optics.
  • Quantum dots.
  • Rigorous theories for the description of the polarization effects in matter.

Dr. Aggelos Avramopoulos
Guest Editor

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Published Papers (1 paper)

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Research

20 pages, 6824 KiB  
Article
Comparative Validation of Scintillator Materials for X-Ray-Mediated Neuronal Control in the Deep Brain
by Mercedes Hildebrandt, Masanori Koshimizu, Yasuki Asada, Kansai Fukumitsu, Mahito Ohkuma, Na Sang, Takashi Nakano, Toshiaki Kunikata, Kai Okazaki, Noriaki Kawaguchi, Takayuki Yanagida, Linyuan Lian, Jianbing Zhang and Takayuki Yamashita
Int. J. Mol. Sci. 2024, 25(21), 11365; https://doi.org/10.3390/ijms252111365 - 22 Oct 2024
Cited by 2 | Viewed by 1485
Abstract
When exposed to X-rays, scintillators emit visible luminescence. X-ray-mediated optogenetics employs scintillators for remotely activating light-sensitive proteins in biological tissue through X-ray irradiation. This approach offers advantages over traditional optogenetics, allowing for deeper tissue penetration and wireless control. Here, we assessed the short-term [...] Read more.
When exposed to X-rays, scintillators emit visible luminescence. X-ray-mediated optogenetics employs scintillators for remotely activating light-sensitive proteins in biological tissue through X-ray irradiation. This approach offers advantages over traditional optogenetics, allowing for deeper tissue penetration and wireless control. Here, we assessed the short-term safety and efficacy of candidate scintillator materials for neuronal control. Our analyses revealed that lead-free halide scintillators, such as Cs3Cu2I5, exhibited significant cytotoxicity within 24 h and induced neuroinflammatory effects when injected into the mouse brain. In contrast, cerium-doped gadolinium aluminum gallium garnet (Ce:GAGG) nanoparticles showed no detectable cytotoxicity within the same period, and injection into the mouse brain did not lead to observable neuroinflammation over four weeks. Electrophysiological recordings in the cerebral cortex of awake mice showed that X-ray-induced radioluminescence from Ce:GAGG nanoparticles reliably activated 45% of the neuronal population surrounding the implanted particles, a significantly higher activation rate than europium-doped GAGG (Eu:GAGG) microparticles, which activated only 10% of neurons. Furthermore, we established the cell-type specificity of this technique by using Ce:GAGG nanoparticles to selectively stimulate midbrain dopamine neurons. This technique was applied to freely behaving mice, allowing for wireless modulation of place preference behavior mediated by midbrain dopamine neurons. These findings highlight the unique suitability of Ce:GAGG nanoparticles for X-ray-mediated optogenetics. The deep tissue penetration, short-term safety, wireless neuronal control, and cell-type specificity of this system offer exciting possibilities for diverse neuroscience applications and therapeutic interventions. Full article
(This article belongs to the Special Issue Advances in Molecular Physics and Optical Materials)
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