Research of Mitochondrial Function, Structure, Dynamics and Intracellular Organization: 3rd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 2023
Special Issue Editor
Interests: mitochondria; mitochondrial function; structure; intracellular organization; heterogeneity; bioenergetics; cardiac; muscles and liver energy metabolism in normal cells and diseases; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria play a central role in maintaining cellular function by energy (ATP) production. They are also a source of reactive oxygen species and pro-apoptotic elements. In addition to oxidative phosphorylation (OXPHOS), mitochondria regulate a wide range of metabolic processes and cellular signaling mechanisms. The importance of mitochondria in many aspects of cell physiology, bioenergetics, normal cell function and ion control (particularly Ca2+) is well known. Changes in mitochondrial function and energy transfer play crucial roles in numerous diseases and in aging. Therefore, the multifaceted and comprehensive analysis of mitochondria is central to studies of energy metabolism and the pathophysiology of human diseases, including ischemia–reperfusion injury, myopathies, neurodegenerative diseases and cancer. The study of mitochondrial oxygen consumption (OXPHOS) can be performed using isolated mitochondria or in situ, in permeabilized cells or muscle fibers. Moreover, changes in mitochondrial structure, dynamics, organization and function can be analyzed by fluorescent imaging.
Dr. Andrey V. Kuznetsov
Guest Editor
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Keywords
- confocal fluorescent imaging
- mitochondria
- energy metabolism
- mitochondrial function
- mitochondrial dynamics
- mitochondrial intracellular organization
- heterogeneity
- metabolic diseases
- reactive oxygen species
- signaling
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