Nrf2 in Redox Signaling: A Double Edged Sword
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 October 2017) | Viewed by 63978
Special Issue Editor
Interests: sepsis; Nrf2; PPARγ; redox signaling; autophagy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In inflammatory processes, release of reactive oxygen species and synthesis of electrophilic compounds are sensed intracellularly by the cap ´n´ collar basic region leucine zipper transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). Nrf2 is mainly regulated posttranslationally via the proteasome. Under control conditions, Nrf2 is bound by the Kelch-like ECH-associated protein 1 (Keap1) dimer, provoking binding of the E3-ligase Cullin-3. Ubiquitination of Nrf2 targets Nrf2 for proteasomal degradation. In response to oxidative or electrophilic stress, Nrf2 is stabilized. Following its translocation to the nucleus it induces the expression of antioxidative and cytoprotective target genes. Therefore, Nrf2 activation is an important therapeutic target in diseases associated with (excessive) inflammation and injury. However, excessive or prolonged Nrf2 activation has also been shown to contribute to tumorigenesis. Taking these important functions of Nrf2 into consideration, understanding the different means of Nrf2 regulation will provide an improved background for setting up new treatment regimes.
This Special Issue, Nrf2 in Redox Signaling: A Double Edged Sword, will cover a selection of recent research topics and current review articles in the field of Nrf2-dependent research about its role in acute and chronic inflammation, and its resolution as well as tumorigenesis. Experimental papers, up-to-date review articles, and commentaries are all welcome.
Prof. Dr. Andreas von Knethen
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Nrf2
- tumorigenesis
- chronic inflammation
- acute inflammation,
- resolution of inflammation
- proteasome
- antigen presentation
- macrophages
- foam cells
- redox signalling
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.