Special Issue "The NLRP3-Inflammasome in Health and Disease"
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 15540
Interests: molecular biology; signal transduction; p75NTR-signaling; apoptosis; autophagy; EMT; renal and peritoneal fibrosis; inflammation; biological activity of natural compounds in cancer and chronic diseases
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NLRP3 inflammasome is a key component of the innate immune system, which is activated by a wide range of pathogen-, host- and environment-derived molecules. NLRP3 Inflammasome activation occurs through a canonical and non-canonical pathway, which culminant event is the production of active caspase-1, able to process pro-IL-1β into its mature protein, IL-1β, that, in turn, is considered a crucial mediator of inflammation. However, the physiological role of NLRP3 in healthy individuals remains incompletely understood.
In the last decades, many in vitro and in vivo studies have demonstrated that the aberrant NLRP3 activation is strongly involved in the pathogenesis of prevalent diseases, including inflammatory bowel disease, coronary heart disease, chronic kidney disease, autoimmune diseases, neurodegenerative diseases and cancer. Furthermore, genetic studies uncovered mutations or genetic variants in NLRP3 inflammasome components, conferring the susceptibility for diseases, such as diabetes and systemic inflammation. Finally, recently it has been proposed that dysregulated epigenetic mechanisms may contribute to the clinical manifestations of autoinflammatory syndromes by upregulating the expression of inflammasome components.
Therefore, it is our pleasure to invite investigators to contribute to this Special Issue with original research articles, aimed to better elucidate the current knowledge of the physiological and pathophysiological mechanisms of NLRP3 inflammasome activation in health and diseases and to propose new therapeutic approaches targeting NLRP3 inflammasome.
Dr. Anna Perri
Manuscript Submission Information
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- mitochondrial dysfunction
- oxidative stress
- IL-1β – IL-18
- genetic variants of NLRP3 inflammasome