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The Significance of the Intestinal Environment in the Brain–Gut Axis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (20 October 2024) | Viewed by 1502

Special Issue Editors


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Guest Editor
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo Medical University, Nishinomiya 663-8501, Japan
Interests: gut microbiome; inflammation; functional gastrointestinal disorders; gut hormone; pathology; carcinogenesis; inflammatory bowel disease; mucosal barrier; immunity; metabolomics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo Medical University, Nishinomiya 663-8501, Japan
Interests: functional gastrointestinal disorders; inflammatory bowel disease; motility; clinical trial; pharmacology; neurogastroenterology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The gut–brain axis is not only intimately involved in the pathophysiology of gastrointestinal diseases, but also in psychological or metabolic diseases. The intestinal environment, including the gut microbiome, its related metabolites and mucosal immune cells, greatly affect the functions of the mucosal barrier, the production of gut hormones and the gastrointestinal immune system, playing a pivotal role in the interaction between the gastrointestinal tract and the central nervous system. Conversely, psychological stress is a crucial factor that affects gastrointestinal physiology and the symptoms of patients with various diseases. It is very likely that psychological stress alters the intestinal environment, subsequently playing a role in the pathophysiology of patients with functional gastrointestinal disorders and/or inflammatory bowel disease. Thus, this special issue requires the submitted papers to clarify the mechanisms that govern how the intestinal environment is linked to gastrointestinal disease via the brain–gut axis.

Dr. Hirokazu Fukui
Dr. Toshihiko Tomita
Guest Editors

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Keywords

  • gut microbiome
  • inflammation
  • functional gastrointestinal disorders
  • gut hormone
  • inflammatory bowel disease
  • mucosal barrier
  • immunity
  • intestinal environment
  • brain–gut axis

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Published Papers (1 paper)

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Review

19 pages, 1643 KiB  
Review
The Role of Bacteria-Derived Hydrogen Sulfide in Multiple Axes of Disease
by Aleksandr Birg and Henry C. Lin
Int. J. Mol. Sci. 2025, 26(7), 3340; https://doi.org/10.3390/ijms26073340 - 3 Apr 2025
Cited by 1 | Viewed by 641
Abstract
In this review article, we discuss and explore the role of bacteria-derived hydrogen sulfide. Hydrogen sulfide is a signaling molecule produced endogenously that plays an important role in health and disease. It is also produced by the gut microbiome. In the setting of [...] Read more.
In this review article, we discuss and explore the role of bacteria-derived hydrogen sulfide. Hydrogen sulfide is a signaling molecule produced endogenously that plays an important role in health and disease. It is also produced by the gut microbiome. In the setting of microbial disturbances leading to disruption of intestinal homeostasis (dysbiosis), the concentration of available hydrogen sulfide can also vary leading to pathologic sequelae. The brain–gut axis is the original studied paradigm of gut microbiome and host interaction. In recent years, our understanding of microbial and host interaction has expanded greatly to include specific pathways that have branched into their own axes. These axes share a principal concept of microbiota changes, intestinal permeability, and an inflammatory response, some of which are modulated by hydrogen sulfide (H2S). In this review, we will discuss multiple axes including the gut–immune, gut–heart, and gut–endocrine axes. We will evaluate the role of H2S in modulation of intestinal barrier, mucosal healing in intestinal inflammation and tumor genesis. We will also explore the role of H2S in alpha-synuclein aggregation and ischemic injury. Finally, we will discuss H2S in the setting of metabolic syndrome as int pertains to hypertension, atherosclerosis and glucose-like peptide-1 activity. Majority of studies that evaluate hydrogen sulfide focus on endogenous production; the role of this review is to examine the lesser-known bacteria-derived source of hydrogen sulfide in the progression of diseases as it relates to these axes. Full article
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