State-of-the-Art Molecular Oncology in Israel

Dear Colleagues,

The field of molecular Oncology is greatly benefited due to advances in bioinformatics tools and sequencing technologies. Information on DNA methylation, gene expression and copy number alterations altogether provide a tipoff as to the complexity of human cancer.  Nonetheless, merely providing a list of genomic variations is the first stage in the long endeavor for translating this information to cancer therapeutics.

DNA characterization as part of the oncological clinical care and research today is one of the leading aspects in the Oncologist research. Available capabilities in the tool-box utilize a panel of sequencing applications among of which are  massive parallel -, whole exome - and whole genome sequencing. These  are  routinely applied now on clinical samples including plasma and formalin fixed paraffin embedded tissue. In parallel, enhanced know-hows in bioinformatics serve to better extract the pertinent data for a research question.

Immunotherapy has changed the landscape of cancer therapy. The discovery of cancer immune checkpoints have practically reformed the war against cancer. Research in cancer immunotherapy has greatly enhanced our understanding in harnessing  the human immune response.

Although genomic, transcriptomic and immunohistochemical analyses of tumor tissues have immensely contributed to early-detection diagnostic and provide a wealth of information,  understanding the molecular mechanism of cancer stem cells is in the frontline. Translational means to eradicate cancer stem cells are highly warranted and the focus of current efforts in Oncology.

Prof. Dr. Rachel Bar-Shavit
Dr. Aviad Zick
Collection Editors

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