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Membrane Trafficking and Metal Homeostasis
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Membrane Trafficking and Metal Homeostasis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 8812

Special Issue Editors

Dr. Roman Polishchuk

E-Mail Website
Guest Editor
Telethon Institute of Genetics and Medicine (TIGEM), Naples 80131, Italy
Interests: Membrane trafficking; Bioimaging; Cell biology and disease mechanisms
Prof. Dr. Fabio Arnesano

E-Mail Website
Guest Editor
Department of Chemistry, University of Bari “A. Moro”, via E. Orabona 4, 70125 Bari, Italy
Interests: Bioinorganic Chemistry; Structural Biology; Drug and metal ion transport

Special Issue Information

Dear Colleagues,

Membrane trafficking is a process that orchestrates the delivery of proteins, sugars, and lipids through the biosynthetic and endocytic pathways by membrane bound organelles (called “transport carriers” or “vesicles”). At the cell membrane, endocytosis and exocytosis ensure cell communication with the environment and the exchange of materials. In the cytoplasm, the lysosomal system operates as a focal point, where endocytosis, autophagy, and nutrient sensing converge. Metal-containing substances are carried to the lysosome through membrane flows, while numerous transporters allow for metal ions to move across the lysosomal membrane.

This Special Issue is dedicated to the molecular mechanisms of membrane trafficking, with particular emphasis on the role of lysosomes as regulators of metal homeostasis in health and disease.

Sub-topics:
-Molecular mechanisms of protein sorting
-Advanced microscopy and imaging techniques
-Storage and excretion of essential metal ions and xenobiotics (metal-based drugs and metal nanoparticles)

Dr. Roman Polishchuk
Prof. Dr. Fabio Arnesano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Published Papers (2 papers)

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Review

21 pages, 1007 KiB  
Review
The Crossroads between Host Copper Metabolism and Influenza Infection
by Ludmila V. Puchkova, Irina V. Kiseleva, Elena V. Polishchuk, Massimo Broggini and Ekaterina Yu. Ilyechova
Int. J. Mol. Sci. 2021, 22(11), 5498; https://doi.org/10.3390/ijms22115498 - 23 May 2021
Cited by 10 | Viewed by 2711
Abstract
Three main approaches are used to combat severe viral respiratory infections. The first is preemptive vaccination that blocks infection. Weakened or dead viral particles, as well as genetic constructs carrying viral proteins or information about them, are used as an antigen. However, the [...] Read more.
Three main approaches are used to combat severe viral respiratory infections. The first is preemptive vaccination that blocks infection. Weakened or dead viral particles, as well as genetic constructs carrying viral proteins or information about them, are used as an antigen. However, the viral genome is very evolutionary labile and changes continuously. Second, chemical agents are used during infection and inhibit the function of a number of viral proteins. However, these drugs lose their effectiveness because the virus can rapidly acquire resistance to them. The third is the search for points in the host metabolism the effect on which would suppress the replication of the virus but would not have a significant effect on the metabolism of the host. Here, we consider the possibility of using the copper metabolic system as a target to reduce the severity of influenza infection. This is facilitated by the fact that, in mammals, copper status can be rapidly reduced by silver nanoparticles and restored after their cancellation. Full article
(This article belongs to the Special Issue Membrane Trafficking and Metal Homeostasis)
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22 pages, 2965 KiB  
Review
Copper Homeostasis in Mammals, with Emphasis on Secretion and Excretion. A Review
by Maria C. Linder
Int. J. Mol. Sci. 2020, 21(14), 4932; https://doi.org/10.3390/ijms21144932 - 13 Jul 2020
Cited by 65 | Viewed by 5503
Abstract
One of the hallmarks of Cu metabolism in mammals is that tissue and fluid levels are normally maintained within a very narrow range of concentrations. This results from the ability of the organism to respond to variations in intake from food and drink [...] Read more.
One of the hallmarks of Cu metabolism in mammals is that tissue and fluid levels are normally maintained within a very narrow range of concentrations. This results from the ability of the organism to respond to variations in intake from food and drink by balancing excretion, which occurs mainly via the bile and feces. Although this sounds straightforward and we have already learned a great deal about aspects of this process, the balance between overall intake and excretion occurs over a high background of Cu recycling, which has generally been ignored. In fact, most of the Cu absorbed from the GI tract actually comes from digestive fluids and is constantly “re-used”. A great deal more recycling of Cu probably occurs in the interior, between cells of individual tissues and the fluid of the blood and interstitium. This review presents what is known that is pertinent to understanding these complexities of mammalian Cu homeostasis and indicates where further studies are needed. Full article
(This article belongs to the Special Issue Membrane Trafficking and Metal Homeostasis)
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