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Special Issue "Enhancing Neurological Recovery after Stroke: Potential Therapies and Mechanisms"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 July 2023 | Viewed by 549

Special Issue Editor

Karolinska Institutet, Stockholm, Sweden
Interests: stroke; diabetes; obesity; neuroplasticity; neurogenesis; neuroprotection

Special Issue Information

Dear Colleagues, 

Stroke is a leading cause of permanent disability. Although the handling of acute stroke has improved considerably in the past few decades, recent data revealed that two in three patients with ischemic stroke were either dead or functionally dependent at 5 years post-stroke. This underlines the importance of this clinical problem and the urgency to ameliorate post-stroke functional recovery. Additionally, the role of various stroke comorbidities is not fully understood. Although many studies describe the effect of comorbidities on stroke risk, relatively few have addressed their influence on post-stroke neurological recovery. 

In this Special Issue of the International Journal of Molecular Sciences, authors are invited to submit a wide range of papers related to neurological recovery after stroke. These papers can focus on potential therapeutic strategies and treatment techniques for stroke recovery, as well as describing the effects of stroke comorbidities such as diabetes, hypertension, obesity, and vascular complications. Papers addressing the identification of relevant mechanisms through which stroke recovery could be enhanced are also welcome, as are clinical studies.

Dr. Cesare Patrone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stroke
  • neurological recovery
  • complications
  • comorbidities
  • neuroplasticity
  • neuroinflammation
  • astrocytes
  • oligodendrocytes
  • microglia
  • stem cells

Published Papers (1 paper)

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Research

Article
The Pre-Stroke Induction and Normalization of Insulin Resistance Respectively Worsens and Improves Functional Recovery
Int. J. Mol. Sci. 2023, 24(4), 3989; https://doi.org/10.3390/ijms24043989 - 16 Feb 2023
Viewed by 385
Abstract
Type 2 diabetes (T2D) impairs post-stroke recovery, and the underlying mechanisms are unknown. Insulin resistance (IR), a T2D hallmark that is also closely linked to aging, has been associated with impaired post-stroke recovery. However, whether IR worsens stroke recovery is unknown. We addressed [...] Read more.
Type 2 diabetes (T2D) impairs post-stroke recovery, and the underlying mechanisms are unknown. Insulin resistance (IR), a T2D hallmark that is also closely linked to aging, has been associated with impaired post-stroke recovery. However, whether IR worsens stroke recovery is unknown. We addressed this question in mouse models where early IR, with or without hyperglycemia, was induced by chronic high-fat diet feeding or sucrose supplementation in the drinking water, respectively. Furthermore, we used 10-month-old mice, spontaneously developing IR but not hyperglycemia, where IR was normalized pharmacologically pre-stroke with Rosiglitazone. Stroke was induced by transient middle cerebral artery occlusion and recovery was assessed by sensorimotor tests. Neuronal survival, neuroinflammation and the density of striatal cholinergic interneurons were also assessed by immunohistochemistry/quantitative microscopy. Pre-stroke induction and normalization of IR, respectively, worsened and improved post-stroke neurological recovery. Moreover, our data indicate a potential association of this impaired recovery with exacerbated neuroinflammation and a decreased density of striatal cholinergic interneurons. The global diabetes epidemic and population aging are dramatically increasing the percentage of people in need of post-stroke treatment/care. Our results suggest that future clinical studies should target pre-stroke IR to reduce stroke sequelae in both diabetics and elderly people with prediabetes. Full article
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