Recent Advances of Leukemia Pathophysiology: From Molecular Basis to Targeted Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 8747
Special Issue Editor
Interests: myeloid leukemia; therapy resistance; microenvironment; hypoxia; mRNA translation; RNA-binding proteins
Special Issue Information
Dear Colleagues,
This Special Issue will focus on molecular mechanisms supporting leukemia development, which could be used as targets for precision medicine.
The occurrence of an oncogene is a factor driving malignant transformation, which is followed by deep molecular changes. Variation in gene expression regulation has an impact on the course of cellular processes. Leukemia development is related to the progressive dysregulation of cell signaling due to the affected level of proteins playing a regulatory role in cellular pathways. The basis of this alteration is mostly a malfunction of factors controlling gene expression at the stage of transcription (e.g., DNA methylation, transcription factors) or post-transcriptionally (e.g., splicing, mRNA modification and turnover) through translation process (e.g., mRNA translation initiation or ribosome heterogeneity). Recent advances demonstrate that these factors contribute to cancer progression by an indirect influence on cellular processes essential for cancer cells’ propagation and survival of chemotherapy, such as cell quiescence/proliferation, differentiation, or apoptosis. Moreover, improper control of cell-cycle progression as well as DNA damage signaling and repair enhance genomic instability, pushing forward the progression of leukemia.
The aim of this Special Issue is to highlight recently discovered molecular constituents emerging as potential therapeutic targets, which contribute to leukemia progression and chemo-resistance by affecting cellular signaling, gene expression, post-transcriptional regulation, or protein translation processes. Original papers and reviews are invited for submission.
Dr. Paulina Podszywałow-Bartnicka
Guest Editor
Manuscript Submission Information
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Keywords
- leukemia
- regulation of gene expression
- transcription
- post-transcriptional regulation
- translation
- protein synthesis
- proliferation
- quiescence
- apoptosis
- differentiation
- cell cycle
- DNA damage and repair
- precision medicine
- therapy resistance
- signaling
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