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Opportunities and Challenges in the Use of Live Biotherapeutics to Fight Infections in the Era of Multi-Drug-Resistance

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 81

Special Issue Editor

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Guest Editor
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
Interests: biofilm; biofilm-associated infections; antimicrobial peptides; new antimicrobial agents; host–pathogen interactions; virulence factors; Pseudomonas aeruginosa; Staphylococcus aureus
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Special Issue Information

Dear Colleagues,

The continuous and growing spread of drug-resistant microbial pathogens is a widely recognized global alarm destined to become one of the major public health problems in the years to come. The paucity of new antibiotics on the market demands the identification of non-traditional approaches to target multi-drug-resistant microorganisms.  Among these approaches, the use of live biotherapeutics (LB) or products thereof, is a futuristic but promising strategy against drug-resistant pathogens. A number of products may fall into the LB category, including single bacterial strains (e.g., probiotics), engineered bacterial strains, defined bacterial consortia, single phages or phage mixtures.  The general tactics entail exploiting the natural competition among living entities to control infections or restore a healthy microbiota at distinct body sites. Modalities through which LB may achieve successful eradication or prevent colonization of drug-resistant pathogens include competition for nutrients, saturation of receptors for adhesion, stimulation of immunity, dampening excessive inflammation, other than implementation of a bactericidal effect either directly (e.g., phages) or indirectly through the production of microbicidal metabolites (e.g., bacteriocins, antimicrobial peptides, organic acids, enzymes). This Special Issue aims to collect original research or review articles focusing on the use of LB or their metabolic products as a new class of antimicrobial agents in order to highlight the opportunities, but also the possible obstacles in the translation of LB to the clinic. Particularly welcome will be manuscripts focusing on, but not limited to, the following themes: multiple activities and modes of molecular actions of LB; development of in vitro and in vivo models of infections for rational LB candidate selection; combinatorial synergistic strategies among LB and other antimicrobials; modes of delivery of LB; and personalized strategies of LB administration. We expect that this Special Issue may contribute to boost our understanding on the benefits and molecular mechanisms associated with LB action, which may promote their applications in anti-infective therapy.

This Special Issue is supervised by Giovanna Batoni (University of Pisa) and assisted by Marta Bianchi (University of Pisa).

Prof. Dr. Giovanna Batoni
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • probiotics
  • postbiotics
  • bioengineered probiotics
  • engineered bacterium
  • next-generation probiotics
  • phage
  • phage therapy
  • multi-drug-resistant organisms
  • microbiota replacement
  • live biotherapeutic product

Published Papers

This special issue is now open for submission.
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