Interactions of Cells with Biomaterials for Regenerative Medicine 3.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 33771
Special Issue Editor
Interests: biomaterials; bioceramics; biopolymers; tissue engineering; bone scaffolds; wound dressings; skin substitutes; stem cells; cell culture models; cell-biomaterial interactions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The biomaterials used for regenerative medicine applications should be non-toxic and biocompatible. Biocompatibility has a very broad meaning, including the non-toxicity of the materials; their ability to support cell adhesion, proliferation, and differentiation; as well as their non-immunogenic properties. Therefore, the evaluation of major cell–biomaterial interactions is a key factor in determining the biocompatibility and clinical usefulness of new biomaterials. It is important to know that in vitro tests can effectively replace animal models in the preliminary evaluation of: 1) cytotoxicity; 2) cell adhesion, spreading, and proliferation on a biomaterial; 3) cell differentiation; and 4) immune response to a biomaterial. Despite the possibility of the use of in vitro cellular models for the evaluation of materials’ biocompatibility, researchers still preferentially choose in vivo animal tests for this purpose. Nevertheless, the use of animal models at a preliminary stage or for comparative purposes is against the principles of the ‘3Rs’, aiming to replace, reduce, and refine the use of animals wherever possible.
The main goal of this Special Issue is to highlight the recent progress made in molecular biology and biotechnological techniques that allow a better exploitation of the potential of in vitro cellular models for the biocompatibility testing of novel biomaterials, suggesting molecular mechanisms of cell adhesion, proliferation, and biomaterial-induced activation of immune cells. All papers (reviews and original research articles) dealing with the in vitro and ex vivo determination of cell–biomaterial interactions are welcome. Manuscripts presenting interactions of biomaterials with prokaryotic cells (e.g., antibiofilm or the antibacterial activity of a material) are also encouraged; however, some description of at least basic cytotoxicity tests with eukaryotic cells should be included.
Dr. Agata Przekora
Guest Editor
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Keywords
- ex vivo tissue explant models
- in vitro cellular models
- cell adhesion and spreading on the biomaterial
- cell proliferation and differentiation on the biomaterial
- immune response to biomaterial
- biomaterial interactions with mesenchymal stem cells
- biomaterial-induced macrophage polarization and cytokine release
- bacteria adhesion and biofilm formation on the biomaterials
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